EWSR1-NFATC2 gene fusion in a soft tissue tumor with epithelioid round cell morphology and abundant stroma: a case report and review of the literature.
Sign Up to like & getrecommendations! Published in 2018 at "Human pathology"
DOI: 10.1016/j.humpath.2018.03.020
Abstract: Mesenchymal round cell tumors are a diverse group of neoplasms defined by primitive, often high-grade cytomorphology. The most common molecular alterations detected in these tumors are gene rearrangements involving EWSR1 to one of many fusion… read more here.
Keywords: ewsr1 nfatc2; nfatc2 gene; gene fusion; round cell ... See more keywords
Are EWSR1-NFATc2-positive sarcomas really Ewing sarcomas?
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DOI: 10.1038/s41379-018-0009-7
Abstract: Recently, Charville et al. [1] reported that EWSR1-rearranged fusion proteins mediate the expression of the pairedbox transcription factor PAX7 in Ewing sarcoma. Based on an analysis of a published gene expression microarray dataset (accession code… read more here.
Keywords: sarcomas; nfatc2 positive; ewsr1 nfatc2; ewing sarcoma ... See more keywords
NFATc2-rearranged sarcomas: clinicopathologic, molecular, and cytogenetic study of 7 cases with evidence of AGGRECAN as a novel diagnostic marker
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DOI: 10.1038/s41379-020-0542-z
Abstract: NFATc2-rearranged sarcomas (NFATc2-Sarcomas) are infrequent round cell tumors characterized by EWSR1-NFATc2 fusions and FUS-NFATc2 fusions. Although our knowledge on these neoplasms has increased recently, novel diagnostic tools and more comprehensive series are still needed. Here,… read more here.
Keywords: ewsr1 nfatc2; novel diagnostic; nfatc2 rearranged; study ... See more keywords
Bone Sarcoma With EWSR1-NFATC2 Fusion: Sarcoma With Varied Morphology and Amplification of Fusion Gene Distinct From Ewing Sarcoma
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DOI: 10.1177/1066896919827093
Abstract: Ewing sarcomas are typified by EWSR1 fusion to ETS gene family members. Tumors with fusion partners other than ETS family members and atypical histologic features pose significant diagnostic challenges and controversies as to their classification.… read more here.
Keywords: sarcoma; nfatc2 fusion; ewsr1 nfatc2; fusion gene ... See more keywords