Disease-related cellular protein networks differentially affected under different EGFR mutations in lung adenocarcinoma
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DOI: 10.1038/s41598-020-67894-7
Abstract: It is unclear how epidermal growth factor receptor EGFR major driver mutations (L858R or Ex19del) affect downstream molecular networks and pathways. This study aimed to provide information on the influences of these mutations. The study… read more here.
Keywords: lung adenocarcinoma; egfr; analysis; disease related ... See more keywords
RELAY Subgroup Analyses by EGFR Ex19del and Ex21L858R Mutations for Ramucirumab Plus Erlotinib in Metastatic Non–Small Cell Lung Cancer
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DOI: 10.1158/1078-0432.ccr-21-0273
Abstract: Purpose: In EGFR-mutated metastatic non–small cell lung cancer (NSCLC), outcomes from EGFR tyrosine kinase inhibitors have differed historically by mutation type present, with lower benefit reported in patients with ex21L858R versus ex19del mutations. We investigated… read more here.
Keywords: egfr ex19del; ram erl; ex19del ex21l858r; ex19del ... See more keywords