Aspirin exacerbated respiratory disease (AERD): molecular and cellular diagnostic & prognostic approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular biology reports"
DOI: 10.1007/s11033-021-06240-0
Abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by immune cells dysfunction. This study aimed to investigate the molecular mechanisms involved in AERD pathogenesis. Relevant literatures were identified by a PubMed search (2005-2019) of english language papers… read more here.
Keywords: disease aerd; aspirin exacerbated; respiratory disease; disease ... See more keywords
Aspirin-Exacerbated Respiratory Disease.
Sign Up to like & getrecommendations! Published in 2017 at "Otolaryngologic clinics of North America"
DOI: 10.1016/j.otc.2016.08.007
Abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of asthma, sinonasal polyposis, and aspirin intolerance. The hallmark of the disease is baseline overproduction of cysteinyl leukotrienes via the 5-lipoxygenase pathway, exacerbated by ingestion of… read more here.
Keywords: aspirin exacerbated; respiratory disease; disease; aspirin ... See more keywords
Prostaglandin E2 in NSAID-exacerbated respiratory disease: protection against cysteinyl leukotrienes and group 2 innate lymphoid cells
Sign Up to like & getrecommendations! Published in 2019 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000498
Abstract: Purpose of review The purpose of this review is to describe the recent advances that have been made in understanding the protective role of prostaglandin E2 (PGE2) in aspirin-exacerbated respiratory disease (AERD), known in Europe… read more here.
Keywords: group innate; exacerbated respiratory; respiratory disease; innate lymphoid ... See more keywords
Cellular interactions in aspirin-exacerbated respiratory disease
Sign Up to like & getrecommendations! Published in 2020 at "Current Opinion in Allergy and Clinical Immunology"
DOI: 10.1097/aci.0000000000000712
Abstract: Purpose of review The purpose of this review is to summarize the complex cellular interactions of aspirin-exacerbated respiratory disease (AERD) and how these interactions promote pathogenic mechanisms of AERD. Recent findings In addition to characteristic… read more here.
Keywords: exacerbated respiratory; respiratory disease; interactions aspirin; aspirin exacerbated ... See more keywords
NSAID-exacerbated respiratory disease: a population study
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DOI: 10.1183/23120541.00462-2021
Abstract: Background Nonsteroidal anti-inflammatory drugs (NSAIDs) may exacerbate respiratory symptoms. A recent European Academy of Allergy and Clinical Immunology position paper recommended the use of an acronym, N-ERD (NSAID-exacerbated respiratory disease), for this hypersensitivity associated with… read more here.
Keywords: exacerbated respiratory; respiratory disease; erd; prevalence erd ... See more keywords
Association analysis of ILVBL gene polymorphisms with aspirin-exacerbated respiratory disease in asthma
Sign Up to like & getrecommendations! Published in 2017 at "BMC Pulmonary Medicine"
DOI: 10.1186/s12890-017-0556-6
Abstract: BackgroundWe previously reported that the ILVBL gene on chromosome 19p13.1 was associated with the risk for aspirin-exacerbated respiratory disease (AERD) and the percent decline of forced expired volume in one second (FEV1) after an oral… read more here.
Keywords: aspirin exacerbated; association; ilvbl gene; ilvbl ... See more keywords
Increased expression of serine palmitoyl transferase and ORMDL3 polymorphism are associated with eosinophilic inflammation and airflow limitation in aspirin-exacerbated respiratory disease
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DOI: 10.1371/journal.pone.0240334
Abstract: Background Patients with aspirin-exacerbated respiratory disease (AERD) are known to have poor clinical outcomes. The pathogenic mechanisms have not yet been completely understood. Objective We aimed to assess the involvement of the de-novo synthetic pathway… read more here.
Keywords: aspirin exacerbated; respiratory disease; patients aerd; expression serine ... See more keywords
Comprehensive Analysis of Nasal Polyps Reveals a More Pronounced Type 2 Transcriptomic Profile of Epithelial Cells and Mast Cells in Aspirin-Exacerbated Respiratory Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.850494
Abstract: Chronic rhinosinusitis with nasal polyps is affecting up to 3% of Western populations. About 10% of patients with nasal polyps also suffer from asthma and intolerance to aspirin, a syndrome called aspirin-exacerbated respiratory disease. Although… read more here.
Keywords: nasal polyps; exacerbated respiratory; respiratory disease; aspirin exacerbated ... See more keywords
NSAID-Exacerbated Respiratory Disease (NERD): From Pathogenesis to Improved Care
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2020.01147
Abstract: Nonsteroidal antiinflammatory drug (NSAID)-exacerbated respiratory disease (NERD) is characterized by moderate-to-severe asthma and a higher prevalence of chronic rhinosinusitis/nasal polyps, but is a highly heterogeneous disorder with various clinical manifestations. Two major pathogenic mechanisms are:… read more here.
Keywords: nerd pathogenesis; respiratory disease; nsaid exacerbated; disease ... See more keywords
Blood Basophils Relevance in Chronic Rhinosinusitis with Aspirin-Exacerbated Respiratory Disease
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DOI: 10.3390/diagnostics13111920
Abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by eosinophilic asthma, chronic rhinosinusitis with nasal polyps (CRSwNP) and intolerance to cyclooxygenase-1 inhibitors. Interest is emerging in studying the role of circulating inflammatory cells in CRSwNP pathogenesis and… read more here.
Keywords: exacerbated respiratory; respiratory disease; aspirin exacerbated; group ... See more keywords
Polymorphisms in Human IL4, IL10, and TNF Genes Are Associated with an Increased Risk of Developing NSAID-Exacerbated Respiratory Disease
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13040605
Abstract: Background: The role of genetics in non-steroidal anti-inflammatory drugs (NSAID) exacerbated respiratory disease (NERD) is unclear, with different candidates involved, such as HLA genes, genes related to leukotriene synthesis, and cytokine genes. This study aimed… read more here.
Keywords: exacerbated respiratory; respiratory disease; il4 il10; nsaid exacerbated ... See more keywords