Articles with "examples threonine" as a keyword



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Discovery of the First Examples of Threonine Tyrosine Kinase PROTAC Degraders.

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Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c01768

Abstract: The first examples of threonine tyrosine kinase (TTK) PROTACs were designed and synthesized. Two of the most potent molecules, 8e and 8j, demonstrated strong TTK degradation in COLO-205 human colorectal cancer cells with DC50 values… read more here.

Keywords: first examples; threonine tyrosine; tyrosine kinase; examples threonine ... See more keywords