Articles with "excessive cytoplasmic" as a keyword



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PIKfyve inhibitor cytotoxicity requires AKT suppression and excessive cytoplasmic vacuolation

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Published in 2018 at "Toxicology and Applied Pharmacology"

DOI: 10.1016/j.taap.2018.08.001

Abstract: &NA; PIKfyve phosphoinositide kinase produces PtdIns(3,5)P2 and PtdIns5P and governs a myriad of cellular processes including cytoskeleton rearrangements and cell proliferation. The latter entails rigorous investigation since the cytotoxicity of PIKfyve inhibition is a potential… read more here.

Keywords: excessive cytoplasmic; pikfyve; cytoplasmic vacuolation; inhibitor ... See more keywords