Excessive mechanical stress induced temporomandibular joint osteoarthritis via osteoclasts-mediated osteogenic differentiation of BMSCs.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of oral rehabilitation"
DOI: 10.1111/joor.13360
Abstract: BACKGROUND Bone homeostasis is a dynamic process maintained by osteoblasts and osteoclasts, which may be regulated by excessive mechanical stress (EMS). OBJECTIVES Our study aims to explore the relationship between osteogenic differentiation of BMSCs and… read more here.
Keywords: differentiation bmscs; mechanical stress; excessive mechanical; osteogenic differentiation ... See more keywords
Gsmtx4 Alleviated Osteoarthritis through Piezo1/Calcineurin/NFAT1 Signaling Axis under Excessive Mechanical Strain
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044022
Abstract: Excessive mechanical strain is the prominent risk factor for osteoarthritis (OA), causing cartilage destruction and degeneration. However, the underlying molecular mechanism contributing to mechanical signaling transduction remains unclear in OA. Piezo type mechanosensitive ion channel… read more here.
Keywords: nfat1 signaling; mechanical strain; excessive mechanical; strain ... See more keywords