Articles with "excessive mitophagy" as a keyword



Drp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage.

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Published in 2020 at "Environmental pollution"

DOI: 10.1016/j.envpol.2020.116413

Abstract: Paraquat (PQ) is one of the most widely used herbicides in the world due to its excellent weed control effects. Accumulating evidence has revealed that long-term exposure to PQ can significantly increase the risk of… read more here.

Keywords: paraquat; mediated mitochondrial; excessive mitophagy; mitochondrial fission ... See more keywords

Dl‑3‑n‑Butylphthalide Alleviates Cognitive Impairment in Chronic Cerebral Hypoperfusion: Associations with Mitochondrial Permeability Transition Pore Closure and Suppression of Excessive Mitophagy

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Published in 2025 at "ACS Chemical Neuroscience"

DOI: 10.1021/acschemneuro.4c00826

Abstract: Chronic cerebral hypoperfusion (CCH) results in cognitive impairment, with mitochondrial dysfunction identified as a key contributor. The opening of the mitochondrial permeability transition pore (mPTP) is closely associated with mitochondrial dysfunction and excessive mitophagy, particularly… read more here.

Keywords: cognitive impairment; chronic cerebral; impairment; excessive mitophagy ... See more keywords

ASIC1a Induces Excessive Mitophagy and PANoptosis of Chondrocyte by the Inhibition of SIRT3 Mitochondrial Translocation

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Published in 2025 at "Theranostics"

DOI: 10.7150/thno.116712

Abstract: Rationale: The death of chondrocytes triggered by extracellular acidification represents a critical factor in the degradation of cartilage tissue and bone, thereby exacerbating the progression of rheumatoid arthritis (RA). Our previous research demonstrated that acid-sensing… read more here.

Keywords: panoptosis; mitophagy panoptosis; asic1a; cartilage ... See more keywords