Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS.
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DOI: 10.1021/acs.jmedchem.8b01108
Abstract: Son of sevenless homologue 1 (SOS1) is a guanine nucleotide exchange factor that catalyzes the exchange of GDP for GTP on RAS. In its active form, GTP-bound RAS is responsible for numerous critical cellular processes.… read more here.
Keywords: nucleotide exchange; exchange ras; benzimidazole derived; exchange ... See more keywords