Selective knockout of astrocytic Na+/H+ exchanger isoform 1 reduces astrogliosis, BBB damage, infarction, and improves neurological function after ischemic stroke
Sign Up to like & getrecommendations! Published in 2018 at "Glia"
DOI: 10.1002/glia.23232
Abstract: Stimulation of Na+/H+ exchanger isoform 1 (NHE1) in astrocytes causes ionic dysregulation under ischemic conditions. In this study, we created a Nhe1flox/flox (Nhe1f/f) mouse line with exon 5 of Nhe1 flanked with two loxP sites… read more here.
Keywords: ischemic stroke; exchanger isoform; mice; damage ... See more keywords
Aquaporin‐2 and Na+/H+ exchanger isoform 1 modulate the efficiency of renal cell migration
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DOI: 10.1002/jcp.29320
Abstract: Aquaporin‐2 (AQP2) promotes renal cell migration by the modulation of integrin β1 trafficking and the turnover of focal adhesions. The aim of this study was to investigate whether AQP2 also works in cooperation with Na+/H+… read more here.
Keywords: renal cell; cell migration; cell; exchanger isoform ... See more keywords
Discovery of Tenapanor: A First-in-Class Minimally Systemic Inhibitor of Intestinal Na+/H+ Exchanger Isoform 3
Sign Up to like & getrecommendations! Published in 2022 at "ACS Medicinal Chemistry Letters"
DOI: 10.1021/acsmedchemlett.2c00037
Abstract: We present herein the design, synthesis, and optimization of gut-restricted inhibitors of Na+/H+ exchanger isoform 3 (NHE3). NHE3 is predominantly expressed in the kidney and gastrointestinal tract where it acts as the major absorptive sodium… read more here.
Keywords: tenapanor first; exchanger isoform; first class; minimally systemic ... See more keywords
The Physiological Function and Potential Role of the Ubiquitous Na+/H+ Exchanger Isoform 8 (NHE8): An Overview Data
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DOI: 10.3390/ijms231810857
Abstract: The Na+/H+ exchanger transporters (NHE) play an important role in various biologic processes including Na+ absorption, intracellular pH homeostasis, cell volume regulation, proliferation, and apoptosis. The wide expression pattern and cellular localization of NHEs make… read more here.
Keywords: exchanger isoform; role; function potential; isoform nhe8 ... See more keywords
Depletion of Na+/H+ Exchanger Isoform 1 Increases the Host Cell Resistance to Trypanosoma cruzi Invasion
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DOI: 10.3390/pathogens11111294
Abstract: Na+/H+ exchanger isoform 1 (NHE1), a member of a large family of integral membrane proteins, plays a role in regulating the cortical actin cytoskeleton. Trypanosoma cruzi, the agent of Chagas disease, depends on F-actin rearrangement… read more here.
Keywords: trypanosoma cruzi; invasion; exchanger isoform;