Bilateral Effects of Excipients on Protein Stability: Preferential Interaction Type of Excipient and Surface Aromatic Hydrophobicity of Protein
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2152-0
Abstract: PurposeUnderstanding the mechanism of protein-excipient interaction and illuminating the influencing factors on protein stability are key steps in the rational design of protein formulations. The objective of this study was to assess effects of preferential… read more here.
Keywords: surface aromatic; interaction; stability; preferential interaction ... See more keywords
A new polymer-excipient for ethanol-resistant, sustained-release oral dosage forms
Sign Up to like & getrecommendations! Published in 2021 at "Drug Delivery and Translational Research"
DOI: 10.1007/s13346-020-00892-4
Abstract: The use of alcoholic beverages can cause uncontrolled release of drugs from sustained-release solid oral dosage forms and pose severe risks to patient health. The aim of this work was to design a new polymeric… read more here.
Keywords: oral dosage; sustained release; ethanol; excipient ethanol ... See more keywords
Cinnamyl O-amine functionalized chitosan as a new excipient in direct compressed tablets with improved drug delivery.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2019.08.265
Abstract: The use of chitosan as a potential excipient in pharmaceutical formulations for the delivery of drugs produced via direct compression tableting has been investigated. Chitosan, N-cinnamyl substituted O-amine functionalized chitosan (cinnamyl-chitosan) and microcrystalline cellulose (MCC)… read more here.
Keywords: drug delivery; delivery; cinnamyl; chitosan cinnamyl ... See more keywords
Identifying overarching excipient properties towards an in-depth understanding of process and product performance for continuous twin-screw wet granulation.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.02.028
Abstract: The overall objective of this work is to understand how excipient characteristics influence the process and product performance for a continuous twin-screw wet granulation process. The knowledge gained through this study is intended to be… read more here.
Keywords: product performance; process product; performance continuous; process ... See more keywords
Poly(trehalose methacrylate) as an Excipient for Insulin Stabilization: Mechanism and Safety
Sign Up to like & getrecommendations! Published in 2022 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.2c09301
Abstract: Insulin, the oldest U.S. Food and Drug Administration (FDA)-approved recombinant protein and a World Health Organization (WHO) essential medicine for treating diabetes globally, faces challenges due to its storage instability. One approach to stabilize insulin… read more here.
Keywords: trehalose methacrylate; mechanism; poly trehalose; excipient ... See more keywords
Modification of α-lactose monohydrate as a direct compression excipient using roller compaction
Sign Up to like & getrecommendations! Published in 2018 at "Drug Development and Industrial Pharmacy"
DOI: 10.1080/03639045.2018.1508224
Abstract: Abstract Roller compaction was used to prepare a direct-compressed lactose excipient using crystalline α-lactose monohydrate. The effect of various roller compaction process parameters (compaction pressure, compaction repetition, and speed ratio) on the characteristics of compacted… read more here.
Keywords: roller compaction; excipient; compaction; lactose monohydrate ... See more keywords
The influence of stevia on the flow, shear and compression behavior of sorbitol, a pharmaceutical excipient for direct compression
Sign Up to like & getrecommendations! Published in 2018 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2017.1315132
Abstract: Abstract Good flow and compaction properties are necessary for the manipulation of particulate material in the pharmaceutical industry. The influence of the addition of an alternative sweetener, rebaudioside A, in a concentration 0.2% w/w and… read more here.
Keywords: compression; flow shear; excipient; flow ... See more keywords
The Essential Oil and Hydrolats from Myristica fragrans Seeds with Magnesium Aluminometasilicate as Excipient: Antioxidant, Antibacterial, and Anti-inflammatory Activity
Sign Up to like & getrecommendations! Published in 2020 at "Foods"
DOI: 10.3390/foods9010037
Abstract: Nutmeg (Myristica fragrans) essential oil has antimicrobial, antiseptic, antiparasitic, anti-inflammatory, and antioxidant properties. We have recently demonstrated that hydrodistillation of nutmeg essential oil by applying magnesium aluminometasilicate as an excipient significantly increases both the content… read more here.
Keywords: essential oil; magnesium aluminometasilicate; oil hydrolats; excipient ... See more keywords
Microcrystalline Cellulose Extracted from Native Plants as an Excipient for Solid Dosage Formulations in Drug Delivery
Sign Up to like & getrecommendations! Published in 2020 at "Nanomaterials"
DOI: 10.3390/nano10050975
Abstract: Excipients represent the complement of the active principle in any pharmaceutical form. Their function is to provide stability, protection, and to ensure absorption of the drug and acceptability in patients. Cellulose is a conventional excipient… read more here.
Keywords: microcrystalline cellulose; excipient; cellulose; solid dosage ... See more keywords
A New Challenge for the Old Excipient Calcium Carbonate: To Improve the Dissolution Rate of Poorly Soluble Drugs
Sign Up to like & getrecommendations! Published in 2023 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics15010300
Abstract: Calcium carbonate is an excipient traditionally used in solid dosage forms with several functions such as a diluent, a quick dissolution agent, a buffer and an opacifier. Recently, many other challenges have arisen for calcium… read more here.
Keywords: dissolution; calcium carbonate; dissolution rate; excipient ... See more keywords
Review on Modification of Glucomannan as an Excipient in Solid Dosage Forms
Sign Up to like & getrecommendations! Published in 2022 at "Polymers"
DOI: 10.3390/polym14132550
Abstract: Glucomannan (GM)—a polysaccharide generally extracted from the tuber of Amorphophallus konjac—has great potential as a filler–binder in direct compression, disintegrant in tablets, or gelling agent due to its strong hydrophilicity and extremely high viscosity. However,… read more here.
Keywords: modification; excipient solid; modification glucomannan; review modification ... See more keywords