Critical Excipient Properties for the Dissolution Enhancement of Phenytoin
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DOI: 10.1021/acsomega.9b02383
Abstract: Solubility-enhancing amorphous solid dispersions can aid in the oral delivery of hydrophobic, poorly soluble drugs. Effective solid dispersion excipients enable high supersaturation drug concentrations over biologically relevant time scales. The critical characteristics of an excipient… read more here.
Keywords: excipient properties; properties dissolution; solid dispersions; phenytoin ... See more keywords
Evaluation of In-Die Compression Data for a Deeper Understanding of Altered Excipient Properties upon Temperature Rise
Sign Up to like & getrecommendations! Published in 2023 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-023-02554-3
Abstract: The thermodynamic analysis of tablet formation includes the thermal and mechanical analysis during compression. The aim of this study was to evaluate alterations of force–displacement data upon temperature rise as an indicator for changed excipient… read more here.
Keywords: upon temperature; temperature; work; compression ... See more keywords