Fluctuation of primary motor cortex excitability during cataplexy in narcolepsy
Sign Up to like & getrecommendations! Published in 2019 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.670
Abstract: Cataplexy is a complicated and dynamic process in narcolepsy type 1 (NT1) patients. This study aimed to clarify the distinct stages during a cataplectic attack and identify the changes of the primary motor cortex (PMC)… read more here.
Keywords: motor cortex; primary motor; fluctuation primary; excitability ... See more keywords
Cortical Excitability Before and After Long‐Term Perampanel Treatment for Epilepsy
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Clinical and Translational Neurology"
DOI: 10.1002/acn3.70044
Abstract: Antiseizure medications (ASMs), which may influence cortical excitability, are the mainstay of epilepsy treatment. Transcranial magnetic stimulation (TMS) helps evaluate cortical excitability. We assessed changes in TMS responses using serial TMS measurements in people treated… read more here.
Keywords: treatment; long term; term perampanel; excitability ... See more keywords
Axonal Excitability Does Not Differ between Painful and Painless Diabetic or Chemotherapy‐Induced Distal Symmetrical Polyneuropathy in a Multicenter Observational Study
Sign Up to like & getrecommendations! Published in 2022 at "Annals of Neurology"
DOI: 10.1002/ana.26319
Abstract: Axonal excitability reflects ion channel function, and it is proposed that this may be a biomarker in painful (vs painless) polyneuropathy. Our objective was to investigate the relationship between axonal excitability parameters and chronic neuropathic… read more here.
Keywords: chemotherapy induced; axonal excitability; excitability; induced distal ... See more keywords
Safety, Pharmacokinetics, and Pharmacodynamics of a First‐in‐Class ClC‐1 Inhibitor to Enhance Muscle Excitability: Phase I Randomized Controlled Trial
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3516
Abstract: NMD670 is a first‐in‐class inhibitor of skeletal muscle‐specific chloride channel ClC‐1, developed to improve muscle weakness and fatigue in neuromuscular diseases. Preclinical studies show that ClC‐1 inhibition enhances muscle excitability, improving muscle contractility and strength.… read more here.
Keywords: first class; muscle excitability; muscle; pharmacokinetics pharmacodynamics ... See more keywords
TMS and EEG Pharmacodynamic Effects of a Selective Sphingosine‐1‐Phosphate Subtype 1 Receptor Agonist on Cortical Excitability in Healthy Subjects
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Pharmacology and Therapeutics"
DOI: 10.1002/cpt.3521
Abstract: Current anti‐epileptic drugs lack efficacy, cause many side effects and one third of all patients are treatment‐resistant. Drugs targeting the sphingosine‐1‐phosphate receptor show potential anti‐convulsant effects in animal models and decrease cortical excitability in patients… read more here.
Keywords: sphingosine phosphate; excitability; cortical excitability; receptor ... See more keywords
Loss of glutamate transporter eaat2a leads to aberrant neuronal excitability, recurrent epileptic seizures, and basal hypoactivity
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24106
Abstract: Astroglial excitatory amino acid transporter 2 (EAAT2, GLT‐1, and SLC1A2) regulates the duration and extent of neuronal excitation by removing glutamate from the synaptic cleft. Hence, an impairment in EAAT2 function could lead to an… read more here.
Keywords: excitability; epileptic seizures; glutamate; recurrent ... See more keywords
Astrocytic TCF7L2 Impacts Brain Osmoregulation and Restricts Neuronal Excitability
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DOI: 10.1002/glia.70103
Abstract: Astrocytes differentiate and mature during postnatal development, but the molecular mechanisms linking their maturation to neuronal function remain unclear. We investigated the role of Wnt/β‐catenin signaling and its effector, the transcription factor TCF7L2, in postnatal… read more here.
Keywords: impacts brain; amino acid; tcf7l2 impacts; tcf7l2 ... See more keywords
Motor cortical excitability during voluntary inhibition of involuntary tic movements
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DOI: 10.1002/mds.27479
Abstract: Background: Tics can be voluntarily inhibited. However, the neurophysiology of voluntary tic inhibition remains underexplored. The objective of this study was to explore state‐dependent effects of voluntary tic inhibition on M1 excitability. read more here.
Keywords: excitability voluntary; inhibition; motor cortical; voluntary inhibition ... See more keywords
Taurine Enhances Stretch Reflex Excitability.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-981-13-8023-5_34
Abstract: The purpose of this study was to characterize the effects of taurine (supplementation and acute injection) on the stretch reflex in the ankle muscles, and in particular to compare the effects of chronic taurine supplementation… read more here.
Keywords: muscle; stretch reflex; taurine; excitability ... See more keywords
Time course of changes in corticospinal excitability induced by motor imagery during action observation combined with peripheral nerve electrical stimulation
Sign Up to like & getrecommendations! Published in 2018 at "Experimental Brain Research"
DOI: 10.1007/s00221-018-5454-5
Abstract: While previous studies assessed corticospinal excitability changes during and after motor imagery (MI) or action observation (AO) combined with peripheral nerve electrical stimulation (ES), we examined, for the first time, the time course of corticospinal… read more here.
Keywords: imagery; stimulation; corticospinal excitability; time ... See more keywords
The differential impact of acute microglia activation on the excitability of cholinergic neurons in the mouse medial septum
Sign Up to like & getrecommendations! Published in 2019 at "Brain Structure and Function"
DOI: 10.1007/s00429-019-01905-w
Abstract: The medial septal nucleus is one of the basal forebrain nuclei that projects cholinergic input to the hippocampus and cortex. Two of the hallmarks of Alzheimer’s disease (AD) are a significant loss of cholinergic transmission… read more here.
Keywords: differential impact; cholinergic neurons; excitability; activation ... See more keywords