GABAergic Mechanisms Can Redress the Tilted Balance between Excitation and Inhibition in Damaged Spinal Networks
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Neurobiology"
DOI: 10.1007/s12035-021-02370-5
Abstract: Correct operation of neuronal networks depends on the interplay between synaptic excitation and inhibition processes leading to a dynamic state termed balanced network. In the spinal cord, balanced network activity is fundamental for the expression… read more here.
Keywords: damaged spinal; spinal networks; gabaergic mechanisms; excitation inhibition ... See more keywords
Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.07.024
Abstract: Excitation-inhibition (E-I) imbalance is considered a hallmark of various neurodevelopmental disorders, including schizophrenia and autism. How genetic risk factors disrupt coordinated glutamatergic and GABAergic synapse formation to cause an E-I imbalance is not well understood.… read more here.
Keywords: imbalance; risk; gabaergic; inhibition imbalance ... See more keywords
Interactions between synaptic homeostatic mechanisms: an attempt to reconcile BCM theory, synaptic scaling, and changing excitation/inhibition balance
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.02.003
Abstract: Homeostatic plasticity is proposed to be mediated by synaptic changes, such as synaptic scaling and shifts in the excitation/inhibition balance. These mechanisms are thought to be separate from the Bienenstock, Cooper, Munro (BCM) learning rule,… read more here.
Keywords: inhibition balance; synaptic scaling; excitation inhibition;
Functional consequences of inhibitory plasticity: homeostasis, the excitation-inhibition balance and beyond
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.03.014
Abstract: Computational neuroscience has a long-standing tradition of investigating the consequences of excitatory synaptic plasticity. In contrast, the functions of inhibitory plasticity are still largely nebulous, particularly given the bewildering diversity of interneurons in the brain.… read more here.
Keywords: inhibition balance; plasticity; excitation inhibition; inhibitory plasticity ... See more keywords
Pathway- and Cell-Specific Kappa-Opioid Receptor Modulation of Excitation-Inhibition Balance Differentially Gates D1 and D2 Accumbens Neuron Activity
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2016.12.005
Abstract: Endogenous dynorphin signaling via the kappa-opioid receptor (KOR) in the nucleus accumbens (NAcc) powerfully mediates negative affective states and stress reactivity. Excitatory inputs from the hippocampus and amygdala play a fundamental role in shaping the activity… read more here.
Keywords: opioid receptor; inhibition; modulation excitation; excitation inhibition ... See more keywords
Macroscopic gradients of synaptic excitation and inhibition in the neocortex
Sign Up to like & getrecommendations! Published in 2020 at "Nature Reviews Neuroscience"
DOI: 10.1038/s41583-020-0262-x
Abstract: With advances in connectomics, transcriptome and neurophysiological technologies, the neuroscience of brain-wide neural circuits is poised to take off. A major challenge is to understand how a vast diversity of functions is subserved by parcellated areas… read more here.
Keywords: macroscopic; excitation inhibition; macroscopic gradients; synaptic excitation ... See more keywords
3.4 NEURAL OSCILLATIONS AND EXCITATION/INHIBITION BALANCE IN SCHIZOPHRENIA: A DEVELOPMENTAL PERSPECTIVE
Sign Up to like & getrecommendations! Published in 2018 at "Schizophrenia Bulletin"
DOI: 10.1093/schbul/sby014.006
Abstract: Abstract Background Schizophrenia (ScZ) is a neurodevelopmental disorder that characteristically emerges during the transition from adolescence to adulthood. However, the mechanisms that underlie the expression of psychotic symptoms and cognitive deficits during this developmental period… read more here.
Keywords: neural oscillations; schizophrenia; inhibition balance; excitation inhibition ... See more keywords
Learning-related congruent and incongruent changes of excitation and inhibition in distinct cortical areas
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Biology"
DOI: 10.1101/2022.04.10.487780
Abstract: Excitatory and inhibitory neurons in diverse cortical regions are likely to contribute differentially to the transformation of sensory information into goal-directed motor plans. Here, we investigate the relative changes across mouse sensorimotor cortex in the… read more here.
Keywords: distinct cortical; learning related; related congruent; motor ... See more keywords
Dynamics underlying interictal to ictal transition in temporal lobe epilepsy: insights from a neural mass model
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13812
Abstract: We propose an approach that combines a neural mass model and clinical intracranial electroencephalographic (iEEG) recordings to explore the potential pathophysiological mechanisms (at the neuronal population level) of ictogenesis. Thirty iEEG recordings from 10 temporal… read more here.
Keywords: lobe epilepsy; inhibition; excitation inhibition; temporal lobe ... See more keywords
Experimental increase of blood glucose alters resting state EEG measures of excitation–inhibition balance
Sign Up to like & getrecommendations! Published in 2021 at "Experimental Physiology"
DOI: 10.1113/ep089211
Abstract: What is the central question of this study? Glucose is the dominant energy source for the brain. However, little is known about how glucose metabolism impacts the coordination of network activity in the brain in… read more here.
Keywords: inhibition balance; balance; excitation inhibition; blood glucose ... See more keywords
Exploring the mechanisms underlying excitation/inhibition imbalance in human iPSC-derived models of ASD
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Autism"
DOI: 10.1186/s13229-020-00339-0
Abstract: Autism spectrum disorder (ASD) is a range of neurodevelopmental disorders characterized by impaired social interaction and communication, and repetitive or restricted behaviors. ASD subjects exhibit complex genetic and clinical heterogeneity, thus hindering the discovery of… read more here.
Keywords: exploring mechanisms; models asd; excitation inhibition; ipsc ... See more keywords