Descending projections from the inferior colliculus to the dorsal cochlear nucleus are excitatory
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Comparative Neurology"
DOI: 10.1002/cne.24095
Abstract: Ascending projections of the dorsal cochlear nucleus (DCN) target primarily the contralateral inferior colliculus (IC). In turn, the IC sends bilateral descending projections back to the DCN. We sought to determine the nature of these… read more here.
Keywords: excitatory; cochlear nucleus; inferior colliculus; projections inferior ... See more keywords
Increased Fibronectin Impairs the Function of Excitatory/Inhibitory Synapses in Hirschsprung Disease
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00759-4
Abstract: Although approximately 50% of cases have a known genetic defect, the precise pathogenesis of Hirschsprung disease (HSCR) is still unclear. We recently reported that expression of fibronectin (FN), which is involved in the migration, colonization,… read more here.
Keywords: etiology; excitatory; hirschsprung disease; excitatory inhibitory ... See more keywords
Median preoptic nucleus excitatory neurotransmitters in the maintenance of hypertensive state
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research Bulletin"
DOI: 10.1016/j.brainresbull.2018.06.011
Abstract: The crucial role of the median preoptic nucleus (MnPO) in the maintenance of hydroelectrolytic balance and autonomic regulation have been highlighted. Recently, the participation of the MnPO in the control of sympathetic nerve activity was… read more here.
Keywords: preoptic nucleus; mnpo; excitatory; nucleus excitatory ... See more keywords
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.03.078
Abstract: Dendritic inhibitory synapses are most efficient in modulating excitatory inputs localized on the same dendrite, but it is unknown whether their location is random or regulated. Here, we show that the formation of inhibitory synapses… read more here.
Keywords: mediates local; signaling mediates; excitatory; endocannabinoid signaling ... See more keywords
Experience-Dependent and Differential Regulation of Local and Long-Range Excitatory Neocortical Circuits by Postsynaptic Mef2c
Sign Up to like & getrecommendations! Published in 2017 at "Neuron"
DOI: 10.1016/j.neuron.2016.11.022
Abstract: Development of proper cortical circuits requires an interaction of sensory experience and genetic programs. Little is known of how experience and specific transcription factors interact to determine the development of specific neocortical circuits. Here, we… read more here.
Keywords: excitatory; range excitatory; long range; neocortical circuits ... See more keywords
Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0099-2
Abstract: Mutations in the SCN2A gene encoding a voltage-gated sodium channel Nav1.2 are associated with epilepsies, intellectual disability, and autism. SCN2A gain-of-function mutations cause early-onset severe epilepsies, while loss-of-function mutations cause autism with milder and/or later-onset… read more here.
Keywords: excitatory neurons; excitatory; absence like; haplodeficiency excitatory ... See more keywords
Seizure-induced strengthening of a recurrent excitatory circuit in the dentate gyrus is proconvulsant
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2201151119
Abstract: Significance Better understanding of the initial molecular and cellular processes implicated in epileptogenesis is essential for early therapeutic intervention (i.e., before brain damage becomes irreversible). Uncontrolled activity of recurrent excitatory circuits is a common mechanism… read more here.
Keywords: excitatory circuit; activity; dentate gyrus; excitatory ... See more keywords
Milestone Review: Excitatory amino acid transporters – Beyond their expected function
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15809
Abstract: Glutamate is the major excitatory neurotransmitter in the vertebrate brain, it is critically involved in the function and dysfunction of the central nervous system. The molecular cloning of its ionotropic receptors in the last decade… read more here.
Keywords: system; function; glutamate; milestone review ... See more keywords
Pyramidal tract neurons drive amplification of excitatory inputs to striatum through cholinergic interneurons
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abh4315
Abstract: Corticostriatal connectivity is central for many cognitive and motor processes, such as reinforcement or action initiation and invigoration. The cortical input to the striatum arises from two main cortical populations: intratelencephalic (IT) and pyramidal tract… read more here.
Keywords: excitatory inputs; tract neurons; excitatory; pyramidal tract ... See more keywords
Mossy Cells and Epileptogenesis: From Synaptic Strengthening to Seizures
Sign Up to like & getrecommendations! Published in 2022 at "Epilepsy Currents"
DOI: 10.1177/15357597221137210
Abstract: Seizure-Induced Strengthening of a Recurrent Excitatory Circuit in the Dentate Gyrus Is Proconvulsant Nasrallah K, Frechou MA, Yoon YJ, Persaud S, Gonçalves JT, Castillo PE. Proc Natl Acad Sci. 2022;119(32):e2201151119. doi:10.1073/pnas.2201151119 Epilepsy is a devastating… read more here.
Keywords: mossy cells; activity; excitatory; epilepsy ... See more keywords
Expression of the Excitatory Postsynaptic Scaffolding Protein, Shank3, in Human Brain: Effect of Age and Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.717263
Abstract: Shank3 is a postsynaptic scaffolding protein of excitatory synapses. Mutations or variations of SHANK3 are associated with various psychiatric and neurological disorders. We set to determine its normal expression pattern in the human brain, and… read more here.
Keywords: excitatory; scaffolding protein; postsynaptic scaffolding; expression ... See more keywords