Scalable Measurements of Intrinsic Excitability in Human iPS Cell-Derived Excitatory Neurons Using All-Optical Electrophysiology
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemical Research"
DOI: 10.1007/s11064-018-2694-5
Abstract: Induced pluripotent stem (iPS) cells offer the exciting opportunity for modeling neurological disorders in vitro in the context of a human genetic background. While significant progress has been made in advancing the use of iPS… read more here.
Keywords: excitatory neurons; derived excitatory; cell derived; human ips ... See more keywords
Alzheimer Aβ Assemblies Accumulate in Excitatory Neurons upon Proteasome Inhibition and Kill Nearby NAKα3 Neurons by Secretion
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DOI: 10.1016/j.isci.2019.01.018
Abstract: Summary We identified ∼30-mer amyloid-β protein (Aβ) assemblies, termed amylospheroids, from brains of patients with Alzheimer disease (AD) as toxic entities responsible for neurodegeneration and showed that Na+,K+-ATPase α3 (NAKα3) is the sole target of… read more here.
Keywords: excitatory neurons; proteasome inhibition; assemblies accumulate; accumulate excitatory ... See more keywords
Transcriptome analysis of human induced excitatory neurons supports a strong effect of clozapine on cholesterol biosynthesis
Sign Up to like & getrecommendations! Published in 2021 at "Schizophrenia Research"
DOI: 10.1016/j.schres.2020.12.041
Abstract: Antipsychotics are known to modulate dopamine and other neurotransmitters which is often thought to be the mechanism underlying their therapeutic effects. Nevertheless, other less studied consequences of antipsychotics on neuronal function may contribute to their… read more here.
Keywords: excitatory neurons; transcriptome analysis; cholesterol metabolism; cholesterol ... See more keywords
Higher ambient synaptic glutamate at inhibitory versus excitatory neurons differentially impacts NMDA receptor activity
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-06512-7
Abstract: Selective disruption of synaptic drive to inhibitory neurons could contribute to the pathophysiology of various brain disorders. We have previously identified a GluN2A-selective positive allosteric modulator, GNE-8324, that selectively enhances N-methyl-d-aspartate receptor (NMDAR)-mediated synaptic responses… read more here.
Keywords: excitatory neurons; higher ambient; inhibitory; glutamate inhibitory ... See more keywords
Transcriptomic evidence that von Economo neurons are regionally specialized extratelencephalic-projecting excitatory neurons
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DOI: 10.1038/s41467-020-14952-3
Abstract: von Economo neurons (VENs) are bipolar, spindle-shaped neurons restricted to layer 5 of human frontoinsula and anterior cingulate cortex that appear to be selectively vulnerable to neuropsychiatric and neurodegenerative diseases, although little is known about… read more here.
Keywords: economo neurons; cluster; von economo; excitatory neurons ... See more keywords
A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology
Sign Up to like & getrecommendations! Published in 2018 at "Nature neuroscience"
DOI: 10.1038/s41593-018-0298-7
Abstract: Excitatory neurons are preferentially impaired in early Alzheimer’s disease but the pathways contributing to their relative vulnerability remain largely unknown. Here we report that pathological tau accumulation takes place predominantly in excitatory neurons compared to… read more here.
Keywords: homeostasis signature; excitatory neurons; tau homeostasis; pathology ... See more keywords
Neuron-specific spinal cord translatomes reveal a neuropeptide code for mouse dorsal horn excitatory neurons
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DOI: 10.1038/s41598-021-84667-y
Abstract: The spinal dorsal horn harbors a sophisticated and heterogeneous network of excitatory and inhibitory neurons that process peripheral signals encoding different sensory modalities. Although it has long been recognized that this network is crucial both… read more here.
Keywords: dorsal horn; excitatory neurons; neuron specific; spinal cord ... See more keywords
Nav1.2 haplodeficiency in excitatory neurons causes absence-like seizures in mice
Sign Up to like & getrecommendations! Published in 2018 at "Communications Biology"
DOI: 10.1038/s42003-018-0099-2
Abstract: Mutations in the SCN2A gene encoding a voltage-gated sodium channel Nav1.2 are associated with epilepsies, intellectual disability, and autism. SCN2A gain-of-function mutations cause early-onset severe epilepsies, while loss-of-function mutations cause autism with milder and/or later-onset… read more here.
Keywords: excitatory neurons; excitatory; absence like; haplodeficiency excitatory ... See more keywords
Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep–wake states
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DOI: 10.1038/s42003-020-01215-6
Abstract: Whilst the brain is assumed to exert homeostatic functions to keep the cellular energy status constant under physiological conditions, this has not been experimentally proven. Here, we conducted in vivo optical recordings of intracellular concentration… read more here.
Keywords: excitatory neurons; energy; intracellular atp; cortical excitatory ... See more keywords
Optogenetic activation of VGLUT2-expressing excitatory neurons blocks epileptic seizure-like activity in the mouse entorhinal cortex
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43230
Abstract: We investigated whether an anti-epileptic effect is obtained by selectively activating excitatory neurons expressing ChR2 under the promoter for the synaptic vesicular glutamate transporter 2 (VGLUT2). VGLUT2-expressing cells were optically stimulated while local field potential… read more here.
Keywords: seizure like; excitatory neurons; vglut2 expressing; like activity ... See more keywords
Cortical thickness differences are associated with cellular component morphogenesis of astrocytes and excitatory neurons in nonsuicidal self-injuring youth.
Sign Up to like & getrecommendations! Published in 2022 at "Cerebral cortex"
DOI: 10.1093/cercor/bhac103
Abstract: Nonsuicidal self-injury (NSSI) generally occurs in youth and probably progresses to suicide. An examination of cortical thickness differences (ΔCT) between NSSI individuals and controls is crucial to investigate potential neurobiological correlates. Notably, ΔCT are influenced… read more here.
Keywords: component; morphogenesis astrocytes; component morphogenesis; excitatory neurons ... See more keywords