VTA DA neuron excitatory synapses in Shank3 Δex4–9 mouse line
Sign Up to like & getrecommendations! Published in 2017 at "Synapse"
DOI: 10.1002/syn.21955
Abstract: Several mutations within SHANK3 gene have been identified in Autism Spectrum Disorder patients and several studies have now started to show that those mutations could impact different brain circuits leading to the heterogeneity of the… read more here.
Keywords: ex4 mouse; shank3 ex4; neuron excitatory; synapses shank3 ... See more keywords
Individual differences in the positive outcome from adolescent ketamine treatment in a female mouse model of anorexia nervosa involve drebrin A at excitatory synapses of the medial prefrontal cortex
Sign Up to like & getrecommendations! Published in 2022 at "Synapse"
DOI: 10.1002/syn.22253
Abstract: Anorexia nervosa (AN) is a mental illness with the highest rates of mortality and relapse, and no approved pharmacological treatment. Using an animal model of AN, called activity‐based anorexia (ABA), we showed earlier that a… read more here.
Keywords: drebrin excitatory; anorexia nervosa; excitatory synapses; individual differences ... See more keywords
Distinct in vivo dynamics of excitatory synapses onto cortical pyramidal neurons and parvalbumin-positive interneurons.
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109972
Abstract: Cortical function relies on the balanced activation of excitatory and inhibitory neurons. However, little is known about the organization and dynamics of shaft excitatory synapses onto cortical inhibitory interneurons. Here, we use the excitatory postsynaptic… read more here.
Keywords: onto cortical; pyramidal neurons; parvalbumin positive; synapses onto ... See more keywords
Beyond the AMPA receptor: Diverse roles of SynDIG/PRRT brain-specific transmembrane proteins at excitatory synapses
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2021.03.011
Abstract: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) are responsible for fast excitatory transmission in the brain. Deficits in synaptic transmission underlie a variety of neurological and psychiatric disorders. However, drugs that target AMPARs are challenging to… read more here.
Keywords: syndig prrt; transmembrane; transmembrane proteins; ampar auxiliary ... See more keywords
Heterogeneity of Astrocytic and Neuronal GLT-1 at Cortical Excitatory Synapses, as Revealed by its Colocalization With Na+/K+-ATPase α Isoforms.
Sign Up to like & getrecommendations! Published in 2018 at "Cerebral cortex"
DOI: 10.1093/cercor/bhy203
Abstract: GLT-1, the major glutamate transporter, is expressed at perisynaptic astrocytic processes (PAP) and axon terminals (AxT). GLT-1 is coupled to Na+/K+-ATPase (NKA) α1-3 isoforms, whose subcellular distribution and spatial organization in relationship to GLT-1 are… read more here.
Keywords: glt; atpase; neuronal glt; glt glt ... See more keywords
Molecular Dissection of Neurobeachin Function at Excitatory Synapses
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2018.00028
Abstract: Spines are small protrusions from dendrites where most excitatory synapses reside. Changes in number, shape, and size of dendritic spines often reflect changes of neural activity in entire circuits or at individual synapses, making spines… read more here.
Keywords: domains neurobeachin; molecular dissection; individual domains; function ... See more keywords