Impaired cortico-striatal excitatory transmission triggers epilepsy
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09954-9
Abstract: STXBP1 and SCN2A gene mutations are observed in patients with epilepsies, although the circuit basis remains elusive. Here, we show that mice with haplodeficiency for these genes exhibit absence seizures with spike-and-wave discharges (SWDs) initiated… read more here.
Keywords: transmission; transmission triggers; mice; cortico striatal ... See more keywords
Withdrawal from cocaine conditioning progressively alters AMPA receptor-mediated transmission in the ventral hippocampus.
Sign Up to like & getrecommendations! Published in 2021 at "Addiction biology"
DOI: 10.1111/adb.13101
Abstract: Drugs of abuse, such as cocaine, produce aberrant changes in synaptic transmission and plasticity that emerge throughout withdrawal. One region of the brain that displays a high degree of synaptic plasticity, as well as connectivity… read more here.
Keywords: transmission; cocaine; withdrawal; ventral hippocampus ... See more keywords
It’s a Storm, It’s a Gale: Epilepsy Initiation From the Corticostriatal Circuit
Sign Up to like & getrecommendations! Published in 2019 at "Epilepsy Currents"
DOI: 10.1177/1535759719870514
Abstract: Impaired Cortico-Striatal Excitatory Transmission Triggers Epilepsy Miyamoto H, Tatsukawa T, Shimohata A, Yamagata T, Suzuki T, Amano K, Mazaki E, Raveau M, Ogiwara I, Oba-Asaka A, Hensch TK, Itohara S, Sakimura K, Kobayashi K, Kobayashi… read more here.
Keywords: epilepsy; corticostriatal; transmission; circuit ... See more keywords