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   Articles with "excitotoxicity" as a keyword



Erratum to: O-GlcNAc Glycosylation of nNOS Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity

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recommendations! Published in 2017 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-017-0495-z

Abstract: Ischemic stroke is a dominant health problem with extremely high rates of mortality and disability. The main mechanism of neuronal injury after stroke is excitotoxicity, during which the activation of neuronal nitric oxide synthase (nNOS)… read more here.

Keywords: glcnac; glcnacylation nnos; apoptosis; excitotoxicity ... See more keywords
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Building a Bridge Between NMDAR-Mediated Excitotoxicity and Mitochondrial Dysfunction in Chronic and Acute Diseases

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recommendations! Published in 2020 at "Cellular and Molecular Neurobiology"

DOI: 10.1007/s10571-020-00924-0

Abstract: Glutamate is the major excitatory neurotransmitter in the brain, and it is widely accepted to play a role in synaptic plasticity and excitotoxic cell death. Glutamate binds to several receptors, including ionotropic N-methyl-d-Aspartate receptor (NMDAR),… read more here.

Keywords: excitotoxicity; bridge nmdar; building bridge; calcium ... See more keywords

EAAT2 Activation Regulates Glutamate Excitotoxicity and Reduces Impulsivity in a Rodent Model of Parkinson’s Disease

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recommendations! Published in 2024 at "Molecular Neurobiology"

DOI: 10.1007/s12035-024-04644-0

Abstract: Parkinson’s disease (PD) is a systemic disease characterized by motor and nonmotor impairments. Loss of dopaminergic neurons in the substantia nigra pars compacta region in PD disrupts dopamine-glutamate homeostasis in the corticostriatal circuit, contributing to… read more here.

Keywords: disease; excitotoxicity; parkinson disease; glutamate excitotoxicity ... See more keywords

Mito-Apocynin Protects Against Kainic Acid-Induced Excitotoxicity by Ameliorating Mitochondrial Impairment

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recommendations! Published in 2025 at "Molecular Neurobiology"

DOI: 10.1007/s12035-025-04827-3

Abstract: Neurodegenerative diseases represent significant global health challenges, with rising incidence rates. A substantial body of evidence indicates that excitotoxicity may be a critical target in the context of these diseases. However, effective pharmacological interventions aimed… read more here.

Keywords: apocynin; mito apocynin; acid induced; excitotoxicity ... See more keywords

Viscoelasticity and Volume of Cortical Neurons under Glutamate Excitotoxicity and Osmotic Challenges.

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recommendations! Published in 2020 at "Biophysical journal"

DOI: 10.1016/j.bpj.2020.09.022

Abstract: Neural activity depends on the maintenance of ionic and osmotic homeostasis. Under these conditions, the cell volume must be regulated to maintain optimal neural function. A disturbance in the neuronal volume regulation often occurs in… read more here.

Keywords: osmotic challenges; viscoelastic properties; glutamate excitotoxicity; cortical neurons ... See more keywords
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Clinically mild infantile encephalopathy associated with excitotoxicity

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recommendations! Published in 2017 at "Journal of the Neurological Sciences"

DOI: 10.1016/j.jns.2016.12.043

Abstract: Acute infectious encephalopathy is very frequently observed in children in East Asia including Japan. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype in Japan; however, more than 40%… read more here.

Keywords: mild infantile; excitotoxicity; acute encephalopathy; encephalopathy ... See more keywords

Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences

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recommendations! Published in 2018 at "Neuroscience Letters"

DOI: 10.1016/j.neulet.2017.08.048

Abstract: Over the past several decades, an overwhelming body of research has greatly expanded our understanding of the mechanisms underlying excitotoxicity in brain ischemia as well as in many chronic neurodegenerative diseases. The identification of an… read more here.

Keywords: downstream consequences; excitotoxicity; overview; calcium ... See more keywords

Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity

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recommendations! Published in 2021 at "Neuropharmacology"

DOI: 10.1016/j.neuropharm.2021.108654

Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates redox homeostasis of the cell through regulation of the antioxidant response element genes transcription. Nrf2 also regulates the antiapoptotic Bcl-2 gene. Nrf2… read more here.

Keywords: excitotoxicity; akt gsk3; pathway; glutamate ... See more keywords

Propofol Protects Rat Hypoglossal Motoneurons in an In Vitro Model of Excitotoxicity by Boosting GABAergic Inhibition and Reducing Oxidative Stress

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recommendations! Published in 2017 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2017.10.019

Abstract: In brainstem motor networks, hypoglossal motoneurons (HMs) play the physiological role of driving tongue contraction, an activity critical for inspiration, phonation, chewing and swallowing. HMs are an early target of neurodegenerative diseases like amyotrophic lateral… read more here.

Keywords: propofol; boosting gabaergic; excitotoxicity; inhibition ... See more keywords
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Guanosine Prevents against Glutamatergic Excitotoxicity in C. elegans

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recommendations! Published in 2019 at "Neuroscience"

DOI: 10.1016/j.neuroscience.2019.07.016

Abstract: Glutamatergic neurotransmission is present in most mammalian excitatory synapses and plays a key role in central nervous system homeostasis. When over-activated, it can induce excitotoxicity, which is present in several neuropathologies. The nucleoside guanosine (GUO),… read more here.

Keywords: glt; excitotoxicity; glutamatergic excitotoxicity; glt glt ... See more keywords
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Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown

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recommendations! Published in 2021 at "Trends in Neurosciences"

DOI: 10.1016/j.tins.2021.01.001

Abstract: Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal responses to glutamate. In fact, mitochondria sustain cell bioenergetics, tune intracellular Ca2+ dynamics, and regulate glutamate availability by… read more here.

Keywords: verge nervous; excitotoxicity; mitochondria verge; excitotoxicity revisited ... See more keywords