Erratum to: O-GlcNAc Glycosylation of nNOS Promotes Neuronal Apoptosis Following Glutamate Excitotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0495-z
Abstract: Ischemic stroke is a dominant health problem with extremely high rates of mortality and disability. The main mechanism of neuronal injury after stroke is excitotoxicity, during which the activation of neuronal nitric oxide synthase (nNOS)… read more here.
Keywords: glcnac; glcnacylation nnos; apoptosis; excitotoxicity ... See more keywords
Building a Bridge Between NMDAR-Mediated Excitotoxicity and Mitochondrial Dysfunction in Chronic and Acute Diseases
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DOI: 10.1007/s10571-020-00924-0
Abstract: Glutamate is the major excitatory neurotransmitter in the brain, and it is widely accepted to play a role in synaptic plasticity and excitotoxic cell death. Glutamate binds to several receptors, including ionotropic N-methyl-d-Aspartate receptor (NMDAR),… read more here.
Keywords: excitotoxicity; bridge nmdar; building bridge; calcium ... See more keywords
Viscoelasticity and Volume of Cortical Neurons under Glutamate Excitotoxicity and Osmotic Challenges.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.09.022
Abstract: Neural activity depends on the maintenance of ionic and osmotic homeostasis. Under these conditions, the cell volume must be regulated to maintain optimal neural function. A disturbance in the neuronal volume regulation often occurs in… read more here.
Keywords: osmotic challenges; viscoelastic properties; glutamate excitotoxicity; cortical neurons ... See more keywords
Clinically mild infantile encephalopathy associated with excitotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the Neurological Sciences"
DOI: 10.1016/j.jns.2016.12.043
Abstract: Acute infectious encephalopathy is very frequently observed in children in East Asia including Japan. Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype in Japan; however, more than 40%… read more here.
Keywords: mild infantile; excitotoxicity; acute encephalopathy; encephalopathy ... See more keywords
Beyond the critical point: An overview of excitotoxicity, calcium overload and the downstream consequences
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2017.08.048
Abstract: Over the past several decades, an overwhelming body of research has greatly expanded our understanding of the mechanisms underlying excitotoxicity in brain ischemia as well as in many chronic neurodegenerative diseases. The identification of an… read more here.
Keywords: downstream consequences; excitotoxicity; overview; calcium ... See more keywords
Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108654
Abstract: Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates redox homeostasis of the cell through regulation of the antioxidant response element genes transcription. Nrf2 also regulates the antiapoptotic Bcl-2 gene. Nrf2… read more here.
Keywords: excitotoxicity; akt gsk3; pathway; glutamate ... See more keywords
Propofol Protects Rat Hypoglossal Motoneurons in an In Vitro Model of Excitotoxicity by Boosting GABAergic Inhibition and Reducing Oxidative Stress
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.10.019
Abstract: In brainstem motor networks, hypoglossal motoneurons (HMs) play the physiological role of driving tongue contraction, an activity critical for inspiration, phonation, chewing and swallowing. HMs are an early target of neurodegenerative diseases like amyotrophic lateral… read more here.
Keywords: propofol; boosting gabaergic; excitotoxicity; inhibition ... See more keywords
Guanosine Prevents against Glutamatergic Excitotoxicity in C. elegans
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DOI: 10.1016/j.neuroscience.2019.07.016
Abstract: Glutamatergic neurotransmission is present in most mammalian excitatory synapses and plays a key role in central nervous system homeostasis. When over-activated, it can induce excitotoxicity, which is present in several neuropathologies. The nucleoside guanosine (GUO),… read more here.
Keywords: glt; excitotoxicity; glutamatergic excitotoxicity; glt glt ... See more keywords
Excitotoxicity Revisited: Mitochondria on the Verge of a Nervous Breakdown
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DOI: 10.1016/j.tins.2021.01.001
Abstract: Excitotoxicity is likely to occur in pathological scenarios in which mitochondrial function is already compromised, shaping neuronal responses to glutamate. In fact, mitochondria sustain cell bioenergetics, tune intracellular Ca2+ dynamics, and regulate glutamate availability by… read more here.
Keywords: verge nervous; excitotoxicity; mitochondria verge; excitotoxicity revisited ... See more keywords
Acidotoxicity via ASIC1a Mediates Cell Death during Oxygen Glucose Deprivation and Abolishes Excitotoxicity.
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DOI: 10.1021/acschemneuro.6b00355
Abstract: Ischemic reperfusion (I/R) injury is associated with a complex and multifactorial cascade of events involving excitotoxicity, acidotoxicity, and ionic imbalance. While it is known that acidosis occurs concomitantly with glutamate-mediated excitotoxicity during brain ischemia, it… read more here.
Keywords: excitotoxicity; glucose deprivation; acidotoxicity; oxygen glucose ... See more keywords
Tuberculous meningitis in children is characterized by compartmentalized immune responses and neural excitotoxicity
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DOI: 10.1038/s41467-019-11783-9
Abstract: Tuberculous meningitis (TBM) is the most severe form of TB with high rates of mortality and morbidity. Here we conduct RNA-sequencing on whole blood as well as on ventricular and lumbar cerebrospinal fluid (CSF) of… read more here.
Keywords: meningitis; excitotoxicity; whole blood; tuberculous meningitis ... See more keywords