Possible Role for Toll-Like Receptors in Interaction of Fasciola hepatica Excretory-Secretory Products with Human Monocyte Cell Line.
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DOI: 10.1007/978-1-0716-0475-5_12
Abstract: This chapter presents a proteomic approach to purify and identify native excretory-secretory products (ESPs) in the range of >10-30 kDa proteins capable of interacting with toll-like receptors (TLRs). Here we present a protocol to fractionate the… read more here.
Keywords: toll like; excretory secretory; secretory products; fasciola hepatica ... See more keywords
Immunomodulatory action of excretory-secretory products of Angiostrongylus cantonensis in a mouse tumour model.
Sign Up to like & getrecommendations! Published in 2020 at "Parasitology research"
DOI: 10.1007/s00436-020-06872-4
Abstract: Excretory-secretory products (ESPs) of parasitic helminths are well known to exert immunostimulation and immunomodulation in hosts. Immune regulation plays a key role in anti-tumour therapy. The present study explored the anti-tumour effect of ESPs released… read more here.
Keywords: excretory secretory; secretory products; angiostrongylus cantonensis; mouse tumour ... See more keywords
Metabolomic profiling of the excretory–secretory products of hookworm and whipworm
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DOI: 10.1007/s11306-019-1561-y
Abstract: Soil-transmitted helminths infect billions of people, livestock and companion animals worldwide, and chronic infections with these nematodes represent a major health burden in many developing countries. On the other hand, complete elimination of parasitic helminths… read more here.
Keywords: excretory secretory; secretory products; small molecules; small metabolites ... See more keywords
Functional Diversity of the Excretory/Secretory Proteins of Nematode Parasites.
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DOI: 10.1007/s11686-022-00523-7
Abstract: INTRODUCTION Parasites release a wide array of protein as excretory and secretory products (ESPs). Irrespective of their mode of propagation, ESPs are found to be secreted or excreted by both naturally occurring and laboratory-cultivated parasites.… read more here.
Keywords: diversity; functional diversity; secretory proteins; diversity excretory ... See more keywords
Immunomodulatory effects of Trichinella spiralis excretory-secretory antigens on macrophages.
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DOI: 10.1016/j.exppara.2018.10.001
Abstract: Helminths and their products can suppress the host immune response and other immunopathologies which may benefit parasite survival. Parasitic nematode Trichinella spiralis (T. spiralis) exert immunomodulatory effect on the host immune response through excretory-secretory (ES)… read more here.
Keywords: host immune; excretory secretory; response; trichinella spiralis ... See more keywords
Trichinella spiralis muscle larvae excretory-secretory products induce changes in cytoskeletal and myogenic transcription factors in primary myoblast cultures.
Sign Up to like & getrecommendations! Published in 2018 at "International journal for parasitology"
DOI: 10.1016/j.ijpara.2017.10.002
Abstract: Trichinella spiralis infection in skeletal muscle culminates with nurse cell formation. The participation of excretory-secretory products of the muscle larvae has been implicated in this process through different studies performed in infected muscle and the… read more here.
Keywords: excretory secretory; muscle larvae; muscle; secretory products ... See more keywords
Proteomic characterization of the internalization of Opisthorchis viverrini excretory/secretory products in human cells.
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DOI: 10.1016/j.parint.2016.02.001
Abstract: The association between liver fluke infection caused by Opisthorchis viverrini and cholangiocarcinoma (CCA - hepatic cancer of the bile duct epithelium) has been well established. Multiple mechanisms play a role in the development of CCA,… read more here.
Keywords: excretory secretory; internalization; opisthorchis viverrini; secretory products ... See more keywords
Genome-wide identification and comprehensive analysis of Excretory/Secretory proteins in nematodes provide potential drug targets for parasite control.
Sign Up to like & getrecommendations! Published in 2019 at "Genomics"
DOI: 10.1016/j.ygeno.2018.03.007
Abstract: Nematodes are responsible for causing severe diseases in plants, humans and other animals. Infection is associated with the release of Excretory/Secretory (ES) proteins into host cytoplasm and interference with the host immune system which make… read more here.
Keywords: excretory secretory; secretory proteins; targets parasite; identification ... See more keywords
Review of the Role of Parasitic Nematode Excretory/Secretory Proteins in Host Immunomodulation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Parasitology"
DOI: 10.1645/21-33
Abstract: ABSTRACT Parasitic nematodes infect a variety of organisms including insects and vertebrates. To survive, they evade host immune responses to cause morbidity and mortality. Despite the vast clinical knowledge regarding nematode infections and their biological… read more here.
Keywords: review; excretory secretory; parasitic nematode; host ... See more keywords
Toxoplasma gondii excretory/secretory antigens (TgESAs) suppress pro-inflammatory cytokine secretion by inhibiting TLR-induced NF-κB activation in LPS-stimulated murine macrophages
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DOI: 10.18632/oncotarget.19362
Abstract: Excretory/secretory antigens (ESAs) produced by Toxoplasma gondii enable this parasite to invade and survive within the host cells through immunomodulation. In this study, the modulating effects of T. gondii excretory/secretory antigens (TgESAs) on the Ana-1… read more here.
Keywords: excretory secretory; secretion; secretory antigens; cytokine secretion ... See more keywords
A Preliminary Study on the Antigenic Proteins of Linguatula serrata Nymphal Stage in Sheep with Visceral Linguatulosis
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DOI: 10.22092/ari.2021.352744.1578
Abstract: Scant information is available on the immunological aspect of Linguatula serrata causing linguatulosis in humans and animals. The purpose of this study was to analyze the content of crude somatic extracts(S) and excretory-secretory products (ESP)… read more here.
Keywords: visceral linguatulosis; linguatula serrata; excretory secretory; linguatulosis ... See more keywords