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Published in 2018 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201800686
Abstract: Abextide, synthesized by conjugating an albumin-binding moiety-truncated Evans blue-to glucagon-like peptide 1 receptor (GLP-1R) agonist exendin-4, shows extended drug release and enhanced hypoglycemic effect in diabetic mice. The aim of this study is to evaluate…
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Keywords:
exendin;
effect abextide;
cynomolgus monkeys;
group ... See more keywords
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Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30236
Abstract: The capability of mesenchymal stem cells (MSCs) to repair bone damage and defects has long been investigated. The receptor activator of nuclear factor‐kappa B (RANK), its ligand (RANKL) and the decoy receptor osteoprotegerin (OPG) axis…
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Keywords:
osteogenic differentiation;
mesenchymal stem;
differentiation;
exendin ... See more keywords
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Published in 2020 at "Peptides"
DOI: 10.1016/j.peptides.2019.170158
Abstract: Glucose-dependent insulinotropic polypeptide (GIP) is a product of the Gip gene and acts as an incretin hormone in mammals. Gip is most closely related to the proglucagon (Gcg) and Exendin genes and diverged from these…
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Keywords:
evolution;
gip exendin;
exendin;
gip ... See more keywords
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Published in 2022 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00051
Abstract: High and sustained renal radioactivity accumulation is a major challenge in peptide-based radionuclide imaging and therapy. However, neutral endopeptidase (NEP)-based enzymatic hydrolysis to release and excrete the radioactive fragments has been proven to be an…
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Keywords:
nota mvk;
combined probe;
peptide;
rate ... See more keywords
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Published in 2023 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.3c00117
Abstract: PET imaging of the glucagon-like peptide-1 receptor (GLP-1R) using radiolabeled exendin is a promising imaging method to detect insulinomas. However, high renal accumulation of radiolabeled exendin could hamper the detection of small insulinomas in proximity…
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Keywords:
renal retention;
177lu dota;
nota exendin;
68ga nota ... See more keywords
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Published in 2022 at "ACS sensors"
DOI: 10.1021/acssensors.1c02336
Abstract: Although endogenous peptides and peptide-based therapeutics are both highly relevant to human health, there are few approaches for sensitive biosensing of this class of molecules with minimized workflow. In this work, we have further expanded…
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Keywords:
peptide;
nanostructure;
electrochemical sensing;
sensing peptide ... See more keywords
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Published in 2019 at "Journal of Microencapsulation"
DOI: 10.1080/02652048.2019.1692945
Abstract: Abstract Aim: Aim of this study was to develop exendin-4 and exendin-4/chymostatin loaded self-nanoemulsifying drug delivery system (SNEDDS). Methods: Surfactants and co-surfactants were mixed, oil phase containing exendin-4 or exendin-4/chymostatin was added dropwise for SNEDDS.…
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Keywords:
loaded self;
exendin;
exendin loaded;
exendin chymostatin ... See more keywords
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Published in 2020 at "Diabetes"
DOI: 10.1111/dom.14171
Abstract: The discovery of glucagon-like peptide-1 (GLP-1) and demonstration of its insulin-releasing and glucose-lowering properties represent important milestones leading to the present drug exploitation of the GLP-1 receptor (GLP-1R) as a therapeutic target for both type…
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Keywords:
glp;
insulin;
gila monster;
exendin ... See more keywords
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Published in 2018 at "Journal of Immunology Research"
DOI: 10.1155/2018/5783639
Abstract: Glucagon-like peptide-1 (GLP-1) receptor agonists are an effective treatment approach for type 2 diabetes. Recently, anti-inflammatory effects of GLP-1 receptor agonists have also been reported. Lipopolysaccharide (LPS) induces inflammation and osteoclast formation. In this study,…
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Keywords:
exendin;
bone resorption;
formation;
osteoclast formation ... See more keywords
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Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/4246086
Abstract: Dysregulated hepatic steatosis may lead to chronic liver inflammation and nonalcoholic steatohepatitis (NASH). Recent studies have suggested that exendin-4, a glucagon-like peptide-1 agonist, may be a promising therapeutic for hepatic steatosis and NASH. However, the…
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Keywords:
lysosomal pathway;
steatosis;
hepatic steatosis;
exendin ... See more keywords
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Published in 2022 at "Diabetes Care"
DOI: 10.2337/dc21-2009
Abstract: OBJECTIVE The aim of this study was to assess whether exendin-(9-39) will increase fasting and postprandial plasma glucose and decrease the incidence of hypoglycemia in children with hyperinsulinism (HI). RESEARCH DESIGN AND METHODS This was…
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Keywords:
increase;
group;
hypoglycemia;
exendin ... See more keywords