Skeletal Muscle Mitochondrial Respiration and Exercise Intolerance in Patients With Heart Failure With Preserved Ejection Fraction.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA cardiology"
DOI: 10.1001/jamacardio.2023.0957
Abstract: Importance The pathophysiology of exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF) remains incompletely understood. Multiple lines of evidence suggest that abnormal skeletal muscle metabolism is a key contributor, but the… read more here.
Keywords: exercise; muscle; exercise intolerance; muscle mitochondrial ... See more keywords
Distinguishing exercise intolerance in early-stage pulmonary hypertension with invasive exercise hemodynamics: Rest VE /VCO2 and ETCO2 identify pulmonary vascular disease.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical cardiology"
DOI: 10.1002/clc.23831
Abstract: BACKGROUND Among subjects with exercise intolerance and suspected early-stage pulmonary hypertension (PH), early identification of pulmonary vascular disease (PVD) with noninvasive methods is essential for prompt PH management. HYPOTHESIS Rest gas exchange parameters (minute ventilation… read more here.
Keywords: hemodynamics; rest; early stage; exercise intolerance ... See more keywords
The metabolic and physiologic impairments underlying long COVID associated exercise intolerance
Sign Up to like & getrecommendations! Published in 2024 at "Pulmonary Circulation"
DOI: 10.1002/pul2.70009
Abstract: Abstract Data from invasive CPET (iCPET) revealed long COVID patients have impaired systemic oxygen extraction (EO2), suggesting impaired mitochondrial ATP production. However, it remains uncertain whether the initial severity of SARS‐CoV‐2 infection has implications on… read more here.
Keywords: exercise intolerance; peak vo2; covid patients; long covid ... See more keywords
Right ventriculo–arterial uncoupling and impaired contractile reserve in obese patients with unexplained exercise intolerance
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Applied Physiology"
DOI: 10.1007/s00421-018-3873-4
Abstract: BackgroundRight ventricular (RV) dysfunction and heart failure with preserved ejection fraction may contribute to exercise intolerance in obesity. To further define RV exercise responses, we investigated RV–arterial coupling in obesity with and without development of… read more here.
Keywords: obese epvh; epvh obese; exercise intolerance; obese patients ... See more keywords
Mechanisms of exercise intolerance in heart failure with preserved ejection fraction (HFpEF)
Sign Up to like & getrecommendations! Published in 2025 at "Heart Failure Reviews"
DOI: 10.1007/s10741-025-10504-3
Abstract: Exercise intolerance is a well-established symptom of heart failure with preserved ejection fraction (HFpEF) and is associated with impaired quality of life and worse clinical outcomes. Historically attributed to diastolic dysfunction of the left ventricle,… read more here.
Keywords: exercise intolerance; heart failure; intolerance;
Left Atrial Stiffness Index Independently Predicts Exercise Intolerance and Quality of Life in Older Patients with Obese HFpEF.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of cardiac failure"
DOI: 10.1016/j.cardfail.2021.10.010
Abstract: BACKGROUND Heart failure with preserved ejection fraction (HFpEF) is the fastest growing form of HF and is associated with high morbidity and mortality. The primary chronic symptom in HFpEF is exercise intolerance, associated with reduced… read more here.
Keywords: exercise intolerance; obese hfpef; stiffness; stiffness index ... See more keywords
Exercise intolerance establishment in pulmonary hypertension: Preventive effect of aerobic exercise training.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.118298
Abstract: AIMS 1) Characterize the progression of exercise intolerance in monocrotaline-induced pulmonary hypertension (PH) mice and 2) evaluate the therapeutic effect of aerobic exercise training (AET) on counteracting skeletal and cardiac dysfunction in PH. MAIN METHODS… read more here.
Keywords: exercise intolerance; muscle; dysfunction; effect ... See more keywords
The yield of diagnostic work-up of patients presenting with myalgia, exercise intolerance, or fatigue A prospective observational study
Sign Up to like & getrecommendations! Published in 2017 at "Neuromuscular Disorders"
DOI: 10.1016/j.nmd.2016.12.002
Abstract: Myalgia, fatigue, and exercise intolerance are cause for referral to a neurologist. However, the diagnostic value of history, neurological examination, and ancillary investigations in patients with these symptoms is unknown. This study provides a sound… read more here.
Keywords: ancillary investigations; prospective observational; study; exercise intolerance ... See more keywords
CHA2DS2-VASc score predicts exercise intolerance in young and middle-aged male patients with asymptomatic atrial fibrillation
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-36185-7
Abstract: Exercise intolerance among the clinical symptoms in patients with atrial fibrillation (AF) has usually been masked by their adjusted life style. We sought to assess the role of CHA2DS2-VASc score to predict exercise intolerance in… read more here.
Keywords: vasc score; cha2ds2 vasc; intolerance; exercise intolerance ... See more keywords
Measurement of improvement on repeat exercise intolerance testing for suspected dysautonomia in protracted concussion recovery: a retrospective cohort study.
Sign Up to like & getrecommendations! Published in 2022 at "Physiotherapy theory and practice"
DOI: 10.1080/09593985.2022.2121949
Abstract: BACKGROUND Research has demonstrated concussion likely causes autonomic dysfunction leading to exercise intolerance. OBJECTIVE To measure improvement in exercise intolerance due to suspected dysautonomia associated with protracted concussion recovery, using objective measurements on a Buffalo… read more here.
Keywords: exercise intolerance; exercise; suspected dysautonomia; concussion ... See more keywords
Sensitivity and Specificity of Exercise Intolerance on Graded Exertion Testing for Diagnosing Sport-related Concussion: A Systematic Review and Exploratory Meta-Analysis.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurotrauma"
DOI: 10.1089/neu.2022.0331
Abstract: There is no single gold standard test to diagnose sport-related concussion (SRC). Concussion-related exercise intolerance, i.e., inability to exercise to the individual's appropriate level due to exacerbation of concussion-like symptoms, is a frequent finding in… read more here.
Keywords: exertion testing; concussion; exercise intolerance; specificity ... See more keywords