The role of transforming growth factor-β (TGF-β) in the formation of exhausted CD8 + T cells
Sign Up to like & getrecommendations! Published in 2024 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-024-01394-0
Abstract: CD8 + T cells exert a critical role in eliminating cancers and chronic infections, and can provide long-term protective immunity. However, under the exposure of persistent antigen, CD8 + T cells can differentiate into terminally exhausted CD8 + T cells and… read more here.
Keywords: cd8 cells; role; exhausted cd8; transforming growth ... See more keywords
Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15315-8
Abstract: Combined PARP and immune checkpoint inhibition has yielded encouraging results in ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic profiling and highly multiplexed single-cell imaging on tumor samples from patients enrolled in a… read more here.
Keywords: cd8 cells; immunogenomic profiling; combined parp; exhausted cd8 ... See more keywords
Deciphering the role of histone modifications in memory and exhausted CD8 T cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-99804-0
Abstract: Exhausted CD8 T cells (TEX) arising during chronic infections and cancer have reduced functional capacity and limited fate flexibility that prevents optimal disease control and response to immunotherapies. Compared to memory (TMEM) cells, TEX have… read more here.
Keywords: histone modifications; cd8 cells; memory; tmem tex ... See more keywords
Activation of NKT Cells in an Anti-PD-1-Resistant Tumor Model Enhances Antitumor Immunity by Reinvigorating Exhausted CD8 T Cells.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer research"
DOI: 10.1158/0008-5472.can-18-0734
Abstract: PD-1-based cancer immunotherapy is a successful example of immune checkpoint blockade that provides long-term durable therapeutic effects in patients with cancer across a wide spectrum of cancer types. Accumulating evidence suggests that anti-PD-1 therapy enhances… read more here.
Keywords: anti resistant; cd8 cells; tumor model; exhausted cd8 ... See more keywords
Terminally exhausted CD8+ T cells resistant to PD-1 blockade promote generation and maintenance of aggressive cancer stem cells.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-3864
Abstract: Heterogeneity within the tumor infiltrating lymphocyte (TIL) population limits immunotherapeutic efficacy against cancer. Between two subpopulations of exhausted CD8+ TILs (progenitor-exhausted, TPEX; terminally-exhausted, TTEX), TTEX cells remain unresponsive to anti-PD1 therapy. Deciphering whether and how… read more here.
Keywords: ttex cells; cancer stem; ttex; terminally exhausted ... See more keywords
Abstract 2701: Functionally specialized subsets of exhausted CD8+ T cells mediate tumor control and differentially respond to checkpoint blockade
Sign Up to like & getrecommendations! Published in 2019 at "Immunology"
DOI: 10.1158/1538-7445.am2019-2701
Abstract: T cell dysfunction in the tumor microenvironment (TME) is a hallmark of many cancers. Reinvigoration of T cell function by PD-1 checkpoint blockade can result in striking clinical responses, but is only effective in a… read more here.
Keywords: exhausted cd8; checkpoint blockade; tumor; progenitor exhausted ... See more keywords
Abstract PR005: Adiponectin inhibits high-fat diet feeding-induced tumor growth through restoration of anti-tumor activity of exhausted-CD8+ T cells
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.tumbody-pr005
Abstract: There is a growing appreciation that obesity is one of the significant risk factors for the development of various types of cancers. Obesity has been shown to dysregulate the immune system, including alteration of immune… read more here.
Keywords: adiponectin; cd8 cells; exhausted cd8; tumor ... See more keywords
Persistent pre-exhausted CD8+ T cells shape the tumor immune microenvironment in anaplastic thyroid cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Endocrine-related cancer"
DOI: 10.1530/erc-24-0169
Abstract: Anaplastic Thyroid Cancer (ATC) is an aggressive form of cancer with poor prognosis, heavily influenced by its tumor immune microenvironment (TIME). Understanding the cellular and gene expression dynamics within the TIME is crucial for developing… read more here.
Keywords: cancer; cd8 cells; thyroid cancer; exhausted cd8 ... See more keywords
Integrative single-cell analysis of LUAD: elucidating immune cell dynamics and prognostic modeling based on exhausted CD8+ T cells
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1366096
Abstract: Background The tumor microenvironment (TME) plays a pivotal role in the progression and metastasis of lung adenocarcinoma (LUAD). However, the detailed characteristics of LUAD and its associated microenvironment are yet to be extensively explored. This… read more here.
Keywords: cd8 cells; microenvironment; exhausted cd8; cell ... See more keywords
Bryostatin-1 enhances the proliferation and functionality of exhausted CD8+ T cells by upregulating MAP Kinase 11
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2024.1509874
Abstract: Introduction Bryostatin-1, a potent agonist of the protein kinase C, has been studied for HIV and cancer therapies. In HIV research, it has shown anti-HIV effects during acute infection and reactivation of latent HIV in… read more here.
Keywords: bryostatin; cd8 cells; hiv specific; exhausted cd8 ... See more keywords