Inference of Developmental Hierarchy and Functional States of Exhausted T Cells from Epigenetic Profiles with Deep Learning
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.4c00261
Abstract: Exhausted T cells are a key component of immune cells that play a crucial role in the immune response against cancer and influence the efficacy of immunotherapy. Accurate assessment and measurement of T-cell exhaustion (TEX)… read more here.
Keywords: exhausted cells; cancer; hierarchy functional; states exhausted ... See more keywords
Cancer labs reach beyond exhausted T cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Methods"
DOI: 10.1038/s41592-020-0800-5
Abstract: T cells race to the scene in cancer and infection. To tease out what is special in cancer, scientists widen their scope and tool sets. read more here.
Keywords: exhausted cells; reach beyond; labs reach; beyond exhausted ... See more keywords
Single-cell landscape of dynamic changes in CD8+ T cells, CD4+ T cells and exhausted T cells in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-88377-7
Abstract: Hepatocellular carcinoma has a high incidence and poor prognosis. In this study, we investigated the value of T-cell-related genes in prognosis by single-cell sequencing data in hepatocellular carcinoma. Twelve cases of hepatocellular carcinoma single-cell sequencing… read more here.
Keywords: exhausted cells; cd8 cells; cd4 cells; hepatocellular carcinoma ... See more keywords
Dissecting the heterogeneity of exhausted T cells at the molecular level.
Sign Up to like & getrecommendations! Published in 2022 at "International immunology"
DOI: 10.1093/intimm/dxac016
Abstract: Our understanding of mechanisms underlying T cell exhaustion has been refined by analysis of exhausted T cells at the molecular level. The development and functions of exhausted T cells are regulated by a number of… read more here.
Keywords: cell; cells molecular; exhausted cells; dissecting heterogeneity ... See more keywords
IMMU-26. Reinvigorating exhausted T cells in glioblastoma via PD1-IL2v immunocytokine therapy
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0824
Abstract: Glioblastoma (GBM) remains one of the most lethal primary brain tumors, characterized by profound immunosuppression and resistance to conventional immunotherapy. A hallmark of the GBM microenvironment is the prevalence of functionally exhausted T cells, marked… read more here.
Keywords: effector; tumor; pd1 il2v; exhausted cells ... See more keywords
Abstract 4436: A novel antibody-enabled dual precision targeted protein stabilization (TPS2) that augments anti-tumor immune response by targeting CBL-B inhibitor to exhausted T cells while blocking checkpoint molecule, PD-1
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4436
Abstract: It is well-established that T cells play a key role in the success of cancer immunotherapies. The goals of T cell-targeting therapies have been to restore the effector function of tumor-specific T cells that are… read more here.
Keywords: cbl; exhausted cells; novel antibody; tumor ... See more keywords
Abstract 2089: Spatial profiling of exhausted T cells using high-plex imaging mass cytometry
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-2089
Abstract: The spatial organization and cellular composition of the tumor microenvironment (TME) has the potential to inform clinical and translational researchers about mechanisms of disease progression and therapeutic success. Of particular interest are immune cells, especially… read more here.
Keywords: cancer; exhausted cells; high plex; biology ... See more keywords
Abstract 4838: Epigenetic modulation of polyamine biosynthetic pathways rectifies T cell dysfunction to enhance anti-tumor immunity in lung cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-4838
Abstract: T cell exhaustion, a dysfunctional state caused by prolonged antigen exposure, presents a major challenge in cancer immunotherapy. While immune checkpoint inhibitors show therapeutic promise, they fail to rejuvenate T cells in a terminally exhaustion… read more here.
Keywords: cancer; exhausted cells; lung cancer; polyamine ... See more keywords
Unveiling the power of plumbagin: revitalizing exhausted T cells to combat tongue cancer
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Cell International"
DOI: 10.1186/s12935-025-03892-x
Abstract: Tongue squamous cell carcinoma (TSCC), the most common form of oral cancer, has a poor prognosis associated with immune escape due to T cell exhaustion within the tumor microenvironment (TME). Numerous studies have demonstrated the… read more here.
Keywords: exhausted cells; cancer; plumbagin; tongue cancer ... See more keywords
Baseline Circulating Activated TFH and Tissue-Like Exhausted B Cells Negatively Correlate With Meningococcal C Conjugate Vaccine Induced Antibodies in HIV-Infected Individuals
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.02500
Abstract: Since 2006, meningococcal serogroup C (MenC) conjugate (MCC) vaccines have been supplied by the Brazilian government for HIV-infected children under 13 years old. For measuring protection against MenC, the serum bactericidal antibody (SBA) assay is… read more here.
Keywords: exhausted cells; tfh cells; vaccine induced; vaccine ... See more keywords