Specific blockade CD73 alters the 'exhausted' phenotype of T cells in head and neck squamous cell carcinoma.
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DOI: 10.1002/ijc.31426
Abstract: The adenosine-induced immunosuppression hampers the immune response toward tumor cells and facilitates the tumor cells to evade immunosurveillance. CD73, an ecto-5-nucleotidase, is the ectoenzyme dephosphorylating extracellular AMP to adenosine. Here, using immunocompetent transgenic head and… read more here.
Keywords: neck squamous; cell carcinoma; squamous cell; exhausted phenotype ... See more keywords
Specific blockade CD73 alters the “exhausted” phenotype of T cells in head and neck squamous cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31534
Abstract: The adenosine‐induced immunosuppression hampers the immune response toward tumor cells and facilitates the tumor cells to evade immunosurveillance. CD73, an ecto‐5‐nucleotidase, is the ectoenzyme dephosphorylating extracellular AMP to adenosine. Here, using immunocompetent transgenic head and… read more here.
Keywords: neck squamous; cell carcinoma; squamous cell; exhausted phenotype ... See more keywords