Novel anti-cancer drug COTI-2 synergizes with therapeutic agents and does not induce resistance or exhibit cross-resistance in human cancer cell lines
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DOI: 10.1371/journal.pone.0191766
Abstract: Emerging drug-resistance and drug-associated toxicities are two major factors limiting successful cancer therapy. Combinations of chemotherapeutic drugs have been used in the clinic to improve patient outcome. However, cancer cells can acquire resistance to drugs,… read more here.
Keywords: cross resistance; coti; drug; exhibit cross ... See more keywords