Effect of thyroid hormones on rat exocrine pancreas morphology and function.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117385
Abstract: AIM The influence of thyroid hormones on exocrine pancreas function is poorly understood, and limited to the postnatal development period. Here, we evaluated the effects of hypo- and hyperthyroidism on the morphology and enzyme content… read more here.
Keywords: morphology function; morphology; lipase; thyroid hormones ... See more keywords
Oleic acid ameliorates palmitic acid-induced ER stress and inflammation markers in naive and cerulein-treated exocrine pancreas cells
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20190054
Abstract: Dietary fat overload (typical to obesity) increases the risk of pancreatic pathologies through mechanisms yet to be defined. We previously showed that saturated dietary fat induces pancreatic acinar lipotoxicity and cellular stress. The endoplasmic reticulum… read more here.
Keywords: cer induced; induced stress; exocrine pancreas; stress ... See more keywords
Dataset for the reporting of carcinoma of the exocrine pancreas: recommendations from the International Collaboration on Cancer Reporting (ICCR).
Sign Up to like & getrecommendations! Published in 2021 at "Histopathology"
DOI: 10.1111/his.14540
Abstract: BACKGROUND AND OBJECTIVES Current guidelines for the pathology reporting on pancreatic cancer differ in certain aspects, resulting in divergent reporting practice and a lack of comparability of data. Here we report on a new international… read more here.
Keywords: reporting; pathology; dataset; international collaboration ... See more keywords
The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
Sign Up to like & getrecommendations! Published in 2020 at "Science Advances"
DOI: 10.1126/sciadv.abc5586
Abstract: Preproinsulin-specific CD8+ T cells residing in the exocrine pancreas become attracted to islets in type 1 diabetes. Preproinsulin (PPI) is presumably a crucial islet autoantigen found in patients with type 1 diabetes (T1D) but is… read more here.
Keywords: specific cd8; cd8; cd8 cells; preproinsulin specific ... See more keywords
The endoplasmic reticulum acetyl-CoA transporter AT-1 plays a role in the protective unfolded protein response in the exocrine pancreas
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733158
Abstract: Pancreatic acinar cells are responsible for the synthesis and secretion of digestive enzymes. In order to sustain high rates of secretory protein production, acinar cells rely on adaptive mechanisms to mitigate endoplasmic reticulum (ER) stress… read more here.
Keywords: role; physiology; exocrine pancreas; acetyl coa ... See more keywords
Low Grade Islet but Marked Exocrine Pancreas Inflammation in an Adult with Autoimmune Pre-Diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Case Reports in Endocrinology"
DOI: 10.1155/2019/5863569
Abstract: There is unexplained deficit in size and function of the exocrine pancreas in type 1 diabetes (T1D). We obtained pancreas from an individual with pre-T1D obtained at surgery and addressed the question, what is the… read more here.
Keywords: inflammation; pre t1d; grade islet; low grade ... See more keywords
Decreased α-cell mass and early structural alterations of the exocrine pancreas in patients with type 1 diabetes: An analysis based on the nPOD repository
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DOI: 10.1371/journal.pone.0191528
Abstract: Background and aims Abnormal glucagon secretion and functional alterations of the exocrine pancreas have been described in patients with type 1 diabetes (T1D), but their respective anatomical substrata have seldom been investigated. Our aim was… read more here.
Keywords: cell mass; tissue; area; cell ... See more keywords
Interaction of Exocrine and Endocrine Pancreas in Obesity Ciliopathies
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DOI: 10.2337/db18-54-or
Abstract: Ciliopathies are rare genetic disorders characterized by dysfunction in primary cilia. Two ciliopathies, Alstrom Syndrome and Bardet-Biedl Syndrome (BBS), are characterized by high rates of obesity. However, they have strikingly different rates of diabetes. The… read more here.
Keywords: endocrine pancreas; interaction exocrine; exocrine pancreas; pancreas enzymes ... See more keywords
2053-P: Integrated Blood Flow between Endocrine and Exocrine Pancreas Is Conserved among Multiple Species
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DOI: 10.2337/db20-2053-p
Abstract: Pancreatic islets compose the endocrine pancreas and are considered distinct from the exocrine pancreas in terms of both function and regulation of blood flow. Indeed, enzymatically isolated islets directly respond to glucose and other secretagogues… read more here.
Keywords: blood flow; flow endocrine; blood; exocrine pancreas ... See more keywords
Characteristics and Clinical Course of Diabetes of the Exocrine Pancreas: A Nationwide Population-Based Cohort Study.
Sign Up to like & getrecommendations! Published in 2022 at "Diabetes care"
DOI: 10.2337/dc21-1659
Abstract: OBJECTIVE The natural course of diabetes of the exocrine pancreas (DEP) is not well established. We aimed to compare the risk of insulin initiation, diabetic complications, and mortality between DEP and type 2 diabetes. RESEARCH… read more here.
Keywords: exocrine pancreas; diabetes exocrine; disease; type diabetes ... See more keywords
The Exocrine Pancreas in Cystic Fibrosis in the Era of CFTR Modulation: A Mini Review
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pediatrics"
DOI: 10.3389/fped.2022.914790
Abstract: Cystic fibrosis (CF) is a common disorder of autosomal recessive inheritance, that once conferred a life expectancy of only a few months. Over recent years, significant advances have been made to CF therapeutic approaches, changing… read more here.
Keywords: pancreas cystic; mini review; exocrine pancreas; cystic fibrosis ... See more keywords