A validated UHPLC-MS/MS method for simultaneous quantification of 9 exocyclic DNA adducts induced by 8 aldehydes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical and biomedical analysis"
DOI: 10.1016/j.jpba.2019.113007
Abstract: Human exposure to aldehydes is implicated in several diseases including cancer. These strong electrophilic compounds can react with nucleophilic sites in DNA to form reversible and irreversible modifications. These modifications, if not repaired, can contribute… read more here.
Keywords: dna; validated uhplc; method; uhplc method ... See more keywords
GENOTOXICITY OF ALDEHYDE MIXTURES: PROFILE OF EXOCYCLIC DNA-ADDUCTS AS A BIOMARKER OF EXPOSURE TO TOBACCO SMOKE.
Sign Up to like & getrecommendations! Published in 2020 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2020.05.010
Abstract: Electrophilic compounds present in humans, originating from endogenous processes or pollutant exposures, pose a risk to health though their reaction with nucleophilic sites in protein and DNA. Among this chemical class, aldehydes are mainly present… read more here.
Keywords: genotoxicity aldehyde; aldehyde mixtures; dna; exposure ... See more keywords