Diastereoselective synthesis of diverse 3,2′-pyrrolidinyl bispirooxindoles via 1,3-dipolar cycloaddition reactions of azomethine ylides with exocyclic α,β-unsaturated ketones and in silico studies for prediction of bioactivity
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DOI: 10.1080/00397911.2018.1560472
Abstract: Abstract A three-component highly regio- and diastereoselective 1,3-dipolar cycloaddition reaction between isatin, a series of primary amino acids (10 nos), and exocyclic α,β-unsaturated ketones was developed towards the synthesis of a small library of bispirooxindole… read more here.
Keywords: azomethine ylides; unsaturated ketones; exocyclic unsaturated; dipolar cycloaddition ... See more keywords