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   Articles with "exocyst" as a keyword



Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing

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recommendations! Published in 2017 at "Molecular Neurobiology"

DOI: 10.1007/s12035-017-0857-z

Abstract: The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the… read more here.

Keywords: hair cells; hair; mice; spiral ganglion ... See more keywords

Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex

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recommendations! Published in 2019 at "Cell Reports"

DOI: 10.1016/j.celrep.2019.01.027

Abstract: Summary NDR/LATS kinases regulate multiple aspects of cell polarity and morphogenesis from yeast to mammals. Fission yeast NDR/LATS kinase Orb6 has been proposed to control cell polarity by regulating the Cdc42 guanine nucleotide exchange factor… read more here.

Keywords: kinase orb6; ndr lats; yeast ndr; lats kinase ... See more keywords
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Exocytosis: A New Exocyst Movie

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recommendations! Published in 2019 at "Current Biology"

DOI: 10.1016/j.cub.2018.11.022

Abstract: Using genome editing and advanced light microscopy, a recent study has offered new insights into the dynamic assembly and disassembly of the exocyst complex during vesicle tethering and membrane fusion. read more here.

Keywords: exocytosis new; new exocyst; exocyst movie; biology ... See more keywords

Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2208947119

Abstract: The phosphoinositide-3 kinase (PI-3K)/AKT cell survival pathway is an important pathway activated by EGFR signaling. Here we show, that in addition to previously described critical components of this pathway, i.e., the docking protein Gab1, the… read more here.

Keywords: akt pathway; exocyst; exocyst mediated; exocytosis ... See more keywords

Preassembly and independent trafficking of the exocyst complex in Arabidopsis.

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2519318122

Abstract: Significance The exocyst is a conserved octameric complex essential for tethering secretory vesicles to the plasma membrane in eukaryotic cells. Despite its central role, the mechanism of exocyst assembly and its coordination with cargo trafficking… read more here.

Keywords: complex arabidopsis; exocyst; independent trafficking; exocyst complex ... See more keywords

The C-terminal domain of SEC-10 is fundamental for exocyst function, apical organization, and cell morphogenesis in Neurospora crassa.

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recommendations! Published in 2025 at "Molecular biology of the cell"

DOI: 10.1091/mbc.e25-03-0146

Abstract: The exocyst complex is crucial for vesicles secretion. In Neurospora crassa, apical growth is determined by the Spitzenkörper (SPK), where secretory vesicles accumulate before fusing with the plasma membrane (PM). Exocyst subunits SEC-3, -5, -6,… read more here.

Keywords: neurospora crassa; exocyst; gfp; exocyst function ... See more keywords

Analysis of exocyst function in endodermis reveals its widespread contribution and specificity of action

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recommendations! Published in 2022 at "Plant Physiology"

DOI: 10.1093/plphys/kiac019

Abstract: Abstract The exocyst is the main plasma membrane vesicle-tethering complex in eukaryotes and is composed of eight different subunits. Yet, in plant genomes, many subunits display multiple copies, thought to reflect evolution of complex subtypes… read more here.

Keywords: exocyst; exocyst function; plant; analysis exocyst ... See more keywords

The exocyst complex controls multiple events in the pathway of regulated exocytosis

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recommendations! Published in 2024 at "eLife"

DOI: 10.1101/2023.08.31.555734

Abstract: Eukaryotic cells depend on exocytosis to direct intracellularly synthesized material towards the extracellular space or the plasma membrane, so exocytosis constitutes a basic function for cellular homeostasis and communication between cells. The secretory pathway includes… read more here.

Keywords: maturation; exocyst; exocytosis; plasma membrane ... See more keywords

Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex

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recommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"

DOI: 10.1136/jitc-2022-004820

Abstract: Background Neutrophils kill antibody-opsonized tumor cells using trogocytosis, a unique mechanism of destruction of the target plasma. This previously unknown cytotoxic process of neutrophils is dependent on antibody opsonization, Fcγ receptors and CD11b/CD18 integrins. Here,… read more here.

Keywords: cell; exocyst; tumor cells; tumor ... See more keywords

Abstract Tu119: The exocyst trafficking complex mediates fuel transporter membrane delivery in cardiomyocytes.

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recommendations! Published in 2024 at "Circulation Research"

DOI: 10.1161/res.135.suppl_1.tu119

Abstract: Introduction: To maintain homeostasis, cardiomyocytes (CMs) primarily rely on fatty acid β-oxidation for ATP production facilitated by substrate uptake via fuel transporters. The glucose transporter, GLUT4, and fatty acid translocase, CD36, are directed to the… read more here.

Keywords: exocyst; fuel; membrane delivery; cd36 ... See more keywords

The exocyst complex and Rab5 are required for abscission by localizing ESCRT III subunits to the cytokinetic bridge

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recommendations! Published in 2019 at "Journal of Cell Science"

DOI: 10.1242/jcs.226001

Abstract: ABSTRACT Cytokinesis is the final step of cell division following chromosome segregation that generates two daughter cells. The conserved exocyst complex is required for scission of the intercellular cytokinetic bridge, although the molecular mechanisms it… read more here.

Keywords: escrt iii; rab5; cytokinetic bridge; exocyst complex ... See more keywords