Exocyst Complex Member EXOC5 Is Required for Survival of Hair Cells and Spiral Ganglion Neurons and Maintenance of Hearing
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Neurobiology"
DOI: 10.1007/s12035-017-0857-z
Abstract: The exocyst, an octameric protein complex consisting of Exoc1 through Exoc8, was first determined to regulate exocytosis by targeting vesicles to the plasma membrane in yeast to mice. In addition to this fundamental role, the… read more here.
Keywords: hair cells; hair; mice; spiral ganglion ... See more keywords
Fission Yeast NDR/LATS Kinase Orb6 Regulates Exocytosis via Phosphorylation of the Exocyst Complex
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.01.027
Abstract: Summary NDR/LATS kinases regulate multiple aspects of cell polarity and morphogenesis from yeast to mammals. Fission yeast NDR/LATS kinase Orb6 has been proposed to control cell polarity by regulating the Cdc42 guanine nucleotide exchange factor… read more here.
Keywords: kinase orb6; ndr lats; yeast ndr; lats kinase ... See more keywords
Exocytosis: A New Exocyst Movie
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2018.11.022
Abstract: Using genome editing and advanced light microscopy, a recent study has offered new insights into the dynamic assembly and disassembly of the exocyst complex during vesicle tethering and membrane fusion. read more here.
Keywords: exocytosis new; new exocyst; exocyst movie; biology ... See more keywords
Regulation of EGF-stimulated activation of the PI-3K/AKT pathway by exocyst-mediated exocytosis
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2208947119
Abstract: The phosphoinositide-3 kinase (PI-3K)/AKT cell survival pathway is an important pathway activated by EGFR signaling. Here we show, that in addition to previously described critical components of this pathway, i.e., the docking protein Gab1, the… read more here.
Keywords: akt pathway; exocyst; exocyst mediated; exocytosis ... See more keywords
Analysis of exocyst function in endodermis reveals its widespread contribution and specificity of action
Sign Up to like & getrecommendations! Published in 2022 at "Plant Physiology"
DOI: 10.1093/plphys/kiac019
Abstract: Abstract The exocyst is the main plasma membrane vesicle-tethering complex in eukaryotes and is composed of eight different subunits. Yet, in plant genomes, many subunits display multiple copies, thought to reflect evolution of complex subtypes… read more here.
Keywords: exocyst; exocyst function; plant; analysis exocyst ... See more keywords
Cancer cells resist antibody-mediated destruction by neutrophils through activation of the exocyst complex
Sign Up to like & getrecommendations! Published in 2022 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-004820
Abstract: Background Neutrophils kill antibody-opsonized tumor cells using trogocytosis, a unique mechanism of destruction of the target plasma. This previously unknown cytotoxic process of neutrophils is dependent on antibody opsonization, Fcγ receptors and CD11b/CD18 integrins. Here,… read more here.
Keywords: cell; exocyst; tumor cells; tumor ... See more keywords
The exocyst complex and Rab5 are required for abscission by localizing ESCRT III subunits to the cytokinetic bridge
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.226001
Abstract: ABSTRACT Cytokinesis is the final step of cell division following chromosome segregation that generates two daughter cells. The conserved exocyst complex is required for scission of the intercellular cytokinetic bridge, although the molecular mechanisms it… read more here.
Keywords: escrt iii; rab5; cytokinetic bridge; exocyst complex ... See more keywords
The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis
Sign Up to like & getrecommendations! Published in 2017 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1006063
Abstract: Membrane transport is an essential component of pathogenesis for most infectious organisms. In African trypanosomes, transport to and from the plasma membrane is closely coupled to immune evasion and antigenic variation. In mammals and fungi… read more here.
Keywords: exocyst conserved; role endocytosis; endocytosis; trypanosome exocyst ... See more keywords
dSTIM- and Ral/Exocyst-Mediated Synaptic Release from Pupal Dopaminergic Neurons Sustains Drosophila Flight
Sign Up to like & getrecommendations! Published in 2018 at "eNeuro"
DOI: 10.1523/eneuro.0455-17.2018
Abstract: Abstract Manifestation of appropriate behavior in adult animals requires developmental mechanisms that help in the formation of correctly wired neural circuits. Flight circuit development in Drosophila requires store-operated calcium entry (SOCE) through the STIM/Orai pathway.… read more here.
Keywords: pupal dopaminergic; flight; dopaminergic neurons; exocyst ... See more keywords