Endogenous and exogenous glucocorticoids abolish the efficacy of immune-dependent cancer therapies
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DOI: 10.1080/2162402x.2019.1673635
Abstract: ABSTRACT Glucocorticoids mediate potent anti-inflammatory and immunosuppressive effects. A chronic elevation of the endogenous glucocorticoid tonus subsequent to mental stress, as well as continuous treatment with exogenous glucocorticoids, activate an immunosuppressive transcription factor, TSC22D3, in… read more here.
Keywords: abolish efficacy; exogenous glucocorticoids; glucocorticoids abolish; cancer ... See more keywords