Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-06158-3
Abstract: Diabetes-associated metabolites may aid the identification of new risk variants for type 2 diabetes. Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their association with… read more here.
Keywords: metabolite traits; exome chip; type diabetes; genetic variants ... See more keywords
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
Sign Up to like & getrecommendations! Published in 2018 at "Genome Biology"
DOI: 10.1186/s13059-018-1457-6
Abstract: BackgroundGenome-wide association studies conducted on QRS duration, an electrocardiographic measurement associated with heart failure and sudden cardiac death, have led to novel biological insights into cardiac function. However, the variants identified fall predominantly in non-coding… read more here.
Keywords: identifies novel; analysis; novel loci; exome chip ... See more keywords
Exome-chip association analysis of intracranial aneurysms
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DOI: 10.1212/wnl.0000000000008665
Abstract: Objective To investigate to what extent low-frequency genetic variants (with minor allele frequencies 5 and >0 to test the hypothesis that multiple variants within the same gene are associated with IA risk. Significant results were… read more here.
Keywords: test; intracranial aneurysms; gene; association ... See more keywords