Weighted burden analysis in 200,000 exome-sequenced subjects characterises rare variant effects on BMI
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DOI: 10.1038/s41366-021-01053-4
Abstract: A number of genes have been identified in which rare variants can cause obesity. Here we analyse a sample of exome sequenced subjects from UK Biobank using BMI as a phenotype with the aims of… read more here.
Keywords: weighted burden; sequenced subjects; exome sequenced; burden analysis ... See more keywords
Burden tests can be used to map causal genes for a simple metabolic trait in an exome‐sequenced polyploid mutant population
Sign Up to like & getrecommendations! Published in 2022 at "Plant Biotechnology Journal"
DOI: 10.1111/pbi.13890
Abstract: genetic screens are excellent tool to assign gene function, but it is often necessary to employ map-based cloning to identify the causal genes. This can be laborious and represents a bottleneck in in DNA it… read more here.
Keywords: burden tests; causal genes; exome sequenced; mutant population ... See more keywords