Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Cell"
DOI: 10.1016/j.molcel.2018.09.033
Abstract: Summary Recursive splicing (RS) starts by defining an “RS-exon,” which is then spliced to the preceding exon, thus creating a recursive 5′ splice site (RS-5ss). Previous studies focused on cryptic RS-exons, and now we find… read more here.
Keywords: recursive splicing; junction complex; exon junction; shapes transcriptome ... See more keywords
The exon junction complex is required for stem and progenitor cell maintenance in planarians
Sign Up to like & getrecommendations! Published in 2019 at "Developmental biology"
DOI: 10.1016/j.ydbio.2019.09.010
Abstract: Named for its assembly near exon-exon junctions during pre-mRNA splicing, the exon junction complex (EJC) regulates multiple aspects of RNA biochemistry, including export of spliced mRNAs from the nucleus and translation. Transcriptome analyses have revealed… read more here.
Keywords: exon junction; junction complex; stem progenitor; biology ... See more keywords
Widespread Exon Junction Complex Footprints in the RNA Degradome Mark mRNA Degradation before Steady State Translation[OPEN]
Sign Up to like & getrecommendations! Published in 2020 at "Plant Cell"
DOI: 10.1105/tpc.19.00666
Abstract: Exon junction complex footprints account for a sizable proportion of major RNA degradation intermediates and can serve as markers for mRNA degradation before steady state translation. Exon junction complexes (EJCs) are deposited on mRNAs during… read more here.
Keywords: degradation; degradation steady; steady state; translation ... See more keywords
Exon-dependent transcriptional adaptation by exon-junction complex proteins Y14/RNP-4 and MAGOH/MAG-1 in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010488
Abstract: Transcriptional adaptation is a powerful gene regulation mechanism that can increase genetic robustness. Transcriptional adaptation occurs when a gene is mutated and is mediated by the mutant RNA, rather than by protein feedback loops. We… read more here.
Keywords: transcriptional adaptation; adaptation; exon junction; exon dependent ... See more keywords
An exon junction complex-independent function of Barentsz in neuromuscular synapse growth.
Sign Up to like & getrecommendations! Published in 2021 at "EMBO reports"
DOI: 10.15252/embr.202153231
Abstract: The exon junction complex controls the translation, degradation, and localization of spliced mRNAs, and three of its core subunits also play a role in splicing. Here, we show that a fourth subunit, Barentsz, has distinct… read more here.
Keywords: junction complex; exon junction; synapse growth;
The Exon Junction Complex and Srp54 Contribute to Hedgehog Signaling via ci RNA Splicing in Drosophila melanogaster
Sign Up to like & getrecommendations! Published in 2017 at "Genetics"
DOI: 10.1534/genetics.117.202457
Abstract: Hedgehog (Hh) regulates the Cubitus interruptus (Ci) transcription factor in Drosophila melanogaster by activating full-length Ci-155 and blocking processing to the Ci-75 repressor. However, the interplay between the regulation of Ci-155 levels and activity, as… read more here.
Keywords: 155 levels; rna; junction complex; drosophila melanogaster ... See more keywords
The glycolytic enzyme ALDOA and the exon junction complex protein RBM8A are regulators of ribosomal biogenesis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.954358
Abstract: Cellular growth is a fundamental process of life and must be precisely controlled in multicellular organisms. Growth is crucially controlled by the number of functional ribosomes available in cells. The production of new ribosomes depends… read more here.
Keywords: rbm8a; exon junction; growth; ribosomal biogenesis ... See more keywords
Hemophilia A subjects with an intron-22 gene inversion mutation show CD4+ T-effector responses to multiple epitopes in FVIII
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1128641
Abstract: Background Almost half of severe hemophilia A (HA) is caused by an intron 22 inversion mutation (Int22Inv), which disrupts the 26-exon F8 gene. Inverted F8 mRNA exons 1-22 are transcribed, while F8B mRNA, containing F8… read more here.
Keywords: exon junction; fviii; inversion mutation; mutation ... See more keywords