Probing the mechanisms of two exonuclease domain mutators of DNA polymerase ϵ.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkab1255
Abstract: We report the properties of two mutations in the exonuclease domain of the Saccharomyces cerevisiae DNA polymerase ϵ. One, pol2-Y473F, increases the mutation rate by about 20-fold, similar to the catalytically dead pol2-D290A/E290A mutant. The… read more here.
Keywords: exonuclease domain; dna polymerase; pol2;
Characterization of hotspot exonuclease domain mutations in the DNA polymerase ϵ gene in endometrial cancer
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.1018034
Abstract: Objective This study was aimed to profile hotspot exonuclease domain mutations (EDMs) of the DNA polymerase ϵ gene (POLE) in endometrial cancer (EC) and to investigate the effects of EDMs on tumor cell behavior and… read more here.
Keywords: endometrial cancer; hotspot; hotspot exonuclease; exonuclease domain ... See more keywords