Serum exosomal miR-16-5p functions as a tumor inhibitor and a new biomarker for PD-L1 inhibitor-dependent immunotherapy in lung adenocarcinoma by regulating PD-L1 expression.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer medicine"
DOI: 10.1002/cam4.4638
Abstract: OBJECTIVES We aimed at investigating whether serum exosomal miR-16-5p could be utilized as an immunotherapy biomarker in lung adenocarcinoma (LUAD) patients administered by programmed cell death ligand-1 (PD-L1) inhibitors, and to evaluate its functions in… read more here.
Keywords: inhibitor; expression; exosomal mir; serum exosomal ... See more keywords
Decreased levels of serum exosomal miR‐638 predict poor prognosis in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26650
Abstract: Currently available studies have implicated that exosome‐delivered microRNAs (miRNAs) play crucial roles in human cancer. However, the association of serum exosomal miR‐638 and hepatocellular carcinoma (HCC) remains largely unknown. We aim to investigate the expression… read more here.
Keywords: hcc; serum exosomal; exosomal mir; mir 638 ... See more keywords
Serum exosomal miR‐210 as a potential biomarker for clear cell renal cell carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27347
Abstract: Exosomal microRNAs (miRNAs) are suggested to reflect molecular changes occurring in their cells of origin and are potential indicators in the early detection of cancers. This study aimed to determine whether certain exosomal miRNAs from… read more here.
Keywords: renal cell; mir; mir 210; clear cell ... See more keywords
Downregulation of serum exosomal miR‐320d predicts poor prognosis in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.23239
Abstract: MicroRNAs (miRNAs) is a class of functional regulator of tumorigenesis of human cancer including hepatocellular carcinoma (HCC). However, the potential clinical significance of serum exosomal miR‐320d in HCC has not been elucidated. read more here.
Keywords: hepatocellular carcinoma; serum exosomal; exosomal mir; mir 320d ... See more keywords
Pancreatic β cells control glucose homeostasis via the secretion of exosomal miR‐29 family
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Extracellular Vesicles"
DOI: 10.1002/jev2.12055
Abstract: Abstract Secreted microRNAs (miRNAs) are novel endocrine factors that play essential pathological and physiological roles. Here, we report that pancreatic β cell‐released exosomal miR‐29 family members (miR‐29s) regulate hepatic insulin sensitivity and control glucose homeostasis.… read more here.
Keywords: insulin; glucose homeostasis; secretion; mir 29s ... See more keywords
Exosomal miR‐122 promotes adipogenesis and aggravates obesity through the VDR/SREBF1 axis
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DOI: 10.1002/oby.23365
Abstract: This study examined the effects of miR‐122–enriched exosomes on the expression of vitamin D3 receptor (VDR) and sterol regulatory element‐binding transcription factor 1 (SREBF1) and their roles during adipogenesis. read more here.
Keywords: 122 promotes; obesity; exosomal mir; vdr ... See more keywords
hUC‐MSCs exosomal miR‐451 alleviated acute lung injury by modulating macrophage M2 polarization via regulating MIF‐PI3K‐AKT signaling pathway
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DOI: 10.1002/tox.23639
Abstract: In the previous study, we have proved that exosomal miR‐451 from human umbilical cord mesenchymal stem cells (hUC‐MSCs) attenuated burn‐induced acute lung injury (ALI). However, the mechanism of exosomal miR‐451 in ALI remains unclear. Therefore,… read more here.
Keywords: mir 451; macrophage polarization; huc mscs; exosomal mir ... See more keywords
Exosomal miR-9-5p secreted by bone marrow–derived mesenchymal stem cells alleviates osteoarthritis by inhibiting syndecan-1
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DOI: 10.1007/s00441-020-03193-x
Abstract: Mesenchymal stem cells (MSCs) have been demonstrated to serve as targets for the treatment of osteoarthritis (OA) and exosomes derived from MSCs also display chondroprotective effects. This study aims to investigate the regulatory role of… read more here.
Keywords: mir secreted; mir; secreted bone; stem cells ... See more keywords
Brown adipocyte-derived exosomal miR-132-3p suppress hepatic Srebf1 expression and thereby attenuate expression of lipogenic genes.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.05.090
Abstract: Recent evidence has revealed a novel signaling mechanism through which brown adipose tissue (BAT)-derived exosomal microRNAs (miRNAs) influence hepatic gene expression. Here, we uncover neuronal control of these miRNAs and identify exosomal miR-132-3p as a… read more here.
Keywords: mir 132; srebf1; derived exosomal; expression ... See more keywords
Cancer-associated fibroblasts-derived exosomal miR-17-5p promotes colorectal cancer aggressive phenotype by initiating a RUNX3/MYC/TGF-β1 positive feedback loop.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer letters"
DOI: 10.1016/j.canlet.2020.07.023
Abstract: Cancer-associated fibroblasts (CAFs) are the main stromal cells in the tumour microenvironment (TME). We found that the distribution of CAFs was significantly increased with tumour progression and led to a poor prognosis. In vitro and… read more here.
Keywords: mir; runx3 myc; tgf; cancer ... See more keywords
Exosomal miR-106b serves as a novel marker for lung cancer and promotes cancer metastasis via targeting PTEN.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences"
DOI: 10.1016/j.lfs.2020.117297
Abstract: As novel non-invasive tumor diagnostic biomarkers, exosomal bioactive miRNAs have received increasing attention. Herein, the aim of this study is to explore the clinical values and roles of exosomal miR106b in lung cancer. The exosomal… read more here.
Keywords: cancer; mir 106b; exosomal mir; lung cancer ... See more keywords