Exosome-associated SUMOylation mutant AAV demonstrates improved ocular gene transfer efficiency in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Virus research"
DOI: 10.1016/j.virusres.2020.197966
Abstract: Exosome associated Adeno-associated virus (AAV) vectors have emerged as a promising tool in gene therapy. Recently, we elucidated the role of SUMOylation post-translational modification in AAV2 capsid and demonstrated that capsid modifications at SUMOylation sites,… read more here.
Keywords: sumoylation; exosome associated; ocular gene; gene transfer ... See more keywords
Exosome‐associated microRNA‐375 induces cell proliferation by regulating IGFBP4 upon hepatitis C virus infection
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DOI: 10.1111/mmi.14986
Abstract: Hepatitis C virus (HCV) infection is one of the most common causes of liver cancer. HCV infection causes chronic disease followed by cirrhosis, which often leads to hepatocellular carcinoma (HCC). In this study, we investigated… read more here.
Keywords: proliferation; mir 375; exosome associated; infection ... See more keywords
The Underlying Roles of Exosome-Associated PIGR in Fatty Acid Metabolism and Immune Signaling in Colorectal Cancer
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DOI: 10.1155/2022/4675683
Abstract: The polymeric immunoglobulin receptor (PIGR), an exosome-associated glycoprotein, plays an important role in the occurrence and development of different tumors. This study aimed to investigate whether PIGR is essential for colorectal cancer (CRC). Comprehensive bioinformatics… read more here.
Keywords: pigr; exosome associated; acid metabolism; colorectal cancer ... See more keywords
Identification of Downregulated Exosome-Associated Gene ENPP1 as a Novel Lipid Metabolism and Immune-Associated Biomarker for Hepatocellular Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/4834791
Abstract: Exosome plays an important role in the occurrence and development of tumors, such as hepatocellular carcinoma (LIHC). However, the functions and mechanisms of exosome-associated molecules in LIHC are still underexplored. Here, we investigated the role… read more here.
Keywords: enpp1; metabolism; hepatocellular carcinoma; exosome associated ... See more keywords