Stereochemistry-activity relationship of ceramide-induced exosome production to clear amyloid-β in Alzheimer's disease.
Sign Up to like & getrecommendations! Published in 2023 at "Chirality"
DOI: 10.1002/chir.23568
Abstract: Stereochemistry has a substantial impact on the biological activity of various drugs. We investigated the role of stereochemistry of ceramides in inducing the production of exosomes, a type of extracellular vesicle, from neuronal cells, with… read more here.
Keywords: alzheimer disease; stereochemistry; activity; exosome production ... See more keywords
Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.
Sign Up to like & getrecommendations! Published in 2017 at "Developmental cell"
DOI: 10.1016/j.devcel.2017.11.018
Abstract: Autophagy and autophagy-related genes (Atg) have been attributed prominent roles in tumorigenesis, tumor growth, and metastasis. Extracellular vesicles called exosomes are also implicated in cancer metastasis. Here, we demonstrate that exosome production is strongly reduced… read more here.
Keywords: v1v0 atpase; atg5; metastasis; exosome production ... See more keywords
APC-activated long noncoding RNA inhibits colorectal carcinoma pathogenesis through reduction of exosome production
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Investigation"
DOI: 10.1172/jci122478
Abstract: The adenomatous polyposis coli (APC) gene plays a pivotal role in the pathogenesis of colorectal carcinoma (CRC) but remains a challenge for drug development. Long noncoding RNAs (lncRNAs) are invaluable in identifying cancer pathologies and… read more here.
Keywords: colorectal carcinoma; lncrna apc1; pathogenesis; long noncoding ... See more keywords
Regulation of exosome production and cargo sorting
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.53671
Abstract: Cellular communication can be mediated by the exchange of biological information, mainly in the form of proteins and RNAs. This can occur when extracellular vesicles, such as exosomes, secreted by a donor cell are internalized… read more here.
Keywords: cargo sorting; regulation exosome; exosome production; production cargo ... See more keywords