The Microglial membrane receptor TREM2 mediates exosome secretion to promote phagocytosis of amyloid‐β by microglia
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14336
Abstract: Considerable evidence links the microglial transmembrane receptor TREM2 to the progression of Alzheimer's disease through its involvement in Aβ phagocytosis by microglia. While previous studies have mainly focused on the phagocytic regulation of microglia itself,… read more here.
Keywords: exosome secretion; phagocytosis; receptor trem2;
Multi‐Phenotypic Exosome Secretion Profiling Microfluidic Platform for Exploring Single‐Cell Heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Small Methods"
DOI: 10.1002/smtd.202200717
Abstract: Cellular phenotypic and functional heterogeneities have advanced cancer evolution and treatment resistance. Although exosome‐bound proteins reflect cellular functions, single‐cell exosomes are rarely profiled owing to the lack of effective platforms. Herein, the authors developed an… read more here.
Keywords: cell; platform; exosome secretion; single cell ... See more keywords
The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Investigational New Drugs"
DOI: 10.1007/s10637-019-00759-7
Abstract: Colorectal cancer (CRC) is the most frequently encountered malignancy associated with the rectum or colon, and accumulating evidences have implicated intestinal dysbacteriosis (IDB, disruption of gut microbiome) and exosomes in the pathology of CRC. We… read more here.
Keywords: secretion; inhibitor neticonazole; xenograft; secretion inhibitor ... See more keywords
Periodontal ligament fibroblasts regulate osteoblasts by exosome secretion induced by inflammatory stimuli.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of oral biology"
DOI: 10.1016/j.archoralbio.2019.06.002
Abstract: OBJECTIVES This study evaluated the role of human periodontal ligament fibroblasts (hPDLFs)-derived exosomes in periodontitis progression and discovered whether hPDLFs influence bone remodeling activity via exosome secretion. MATERIALS AND METHODS Exosomes were isolated and quantified… read more here.
Keywords: periodontal ligament; ligament fibroblasts; secretion; gw4869 ... See more keywords
A live cell reporter of exosome secretion and uptake reveals pathfinding behavior of migrating cells
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15747-2
Abstract: Small extracellular vesicles called exosomes affect multiple autocrine and paracrine cellular phenotypes. Understanding the function of exosomes requires a variety of tools, including live imaging. Our previous live-cell reporter, pHluorin-CD63, allows dynamic subcellular monitoring of… read more here.
Keywords: reporter; live cell; cell reporter; exosome secretion ... See more keywords
Simultaneous Inhibition of Glycolysis and Oxidative Phosphorylation Triggers a Multi-Fold Increase in Secretion of Exosomes: Possible Role of 2′3′-cAMP
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-63658-5
Abstract: Exosome secretion by cells is a complex, poorly understood process. Studies of exosomes would be facilitated by a method for increasing their production and release. Here, we present a method for stimulating the secretion of… read more here.
Keywords: secretion; camp; secretion exosomes; iaa dnp ... See more keywords
Hyperthermia promotes exosome secretion by regulating Rab7b while increasing drug sensitivity in adriamycin-resistant breast cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hyperthermia"
DOI: 10.1080/02656736.2022.2029585
Abstract: Abstract Purpose To investigate the mechanism through which hyperthermia promotes exosome secretion and drug sensitivity in adriamycin-resistant breast cancer. Materials and Methods We first evaluated the effect of hyperthermia on adriamycin-resistant breast cancer viability and… read more here.
Keywords: breast cancer; hyperthermia; adriamycin resistant; exosome secretion ... See more keywords
Oxidative stress state inhibits exosome secretion of hPDLCs through a specific mechanism mediated by PRMT1.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of periodontal research"
DOI: 10.1111/jre.13040
Abstract: BACKGROUND AND OBJECTIVES Periodontitis, the most common chronic inflammation characterized by persistent alveolar bone resorption in the periodontitis, affects almost half of the adult population worldwide. Oxidative stress is one of the pathophysiological mechanisms underlying… read more here.
Keywords: hpdlcs; exosome secretion; oxidative stress; prmt1 ... See more keywords
Enterovirus A71 Promotes Exosome Secretion by the Nonstructural Protein 3A Interacting with Rab27a
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03446-22
Abstract: Research has shown that viral infection impacts exosome secretion, but its regulation mechanisms remain poorly understood. Nonstructural protein 3A of EV-A71 interacts with many host factors and is involved in the remodeling of cellular membranes.… read more here.
Keywords: exosome secretion; infection; secretion; nonstructural protein ... See more keywords
Abstract 2349: Investigating the effect of ECM stiffness on macrophage-derived exosome secretion and PDAC organoid progression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2349
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of only 11%. Current treatments that mostly target the cancer cells themselves, have not been able to significantly improve survival rates, meaning there is an urgent… read more here.
Keywords: ecm stiffness; derived exosome; exosome secretion; macrophage derived ... See more keywords
ISGylation – a key to lock the cell gates for preventing the spread of threats
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cell Science"
DOI: 10.1242/jcs.205468
Abstract: ABSTRACT Interferon stimulated gene 15 (ISG15) is an ubiquitin-like protein whose expression and conjugation to targets (ISGylation) is induced by infection, interferon (IFN)-α and -β, ischemia, DNA damage and aging. Attention has historically focused on… read more here.
Keywords: lock cell; isgylation; exosome secretion; cell gates ... See more keywords