Targeted si-RNA with liposomes and exosomes (extracellular vesicles): How to unlock the potential.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2017.01.056
Abstract: The concept of RNA interference therapeutics has been initiated 18 years ago, and the main bottleneck for translation of the technology into therapeutic products remains the delivery of functional RNA molecules into the cell cytoplasm.… read more here.
Keywords: rna liposomes; exosomes extracellular; delivery; rna ... See more keywords
Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication
Sign Up to like & getrecommendations! Published in 2019 at "Nature Cell Biology"
DOI: 10.1038/s41556-018-0250-9
Abstract: The ability of exosomes to transfer cargo from donor to acceptor cells, thereby triggering phenotypic changes in the latter, has generated substantial interest in the scientific community. However, the extent to which exosomes differ from… read more here.
Keywords: extracellular vesicles; exosomes extracellular; uptake exosomes; secretion uptake ... See more keywords
Liposome co-incubation with cancer cells secreted exosomes (extracellular vesicles) with different proteins expressions and different uptake pathways
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32861-w
Abstract: We recently showed that in vitro incubation of cells with liposomes of varying compositions can increase exosome secretion and increase the yield of harvested exosomes (extracellular vesicles, EVs). This might foster their potential therapeutic implementations.… read more here.
Keywords: extracellular vesicles; exosomes extracellular; incubation; exosomes evs ... See more keywords
Exosomes and extracellular vesicles: the path forward.
Sign Up to like & getrecommendations! Published in 2018 at "Essays in biochemistry"
DOI: 10.1042/ebc20170088
Abstract: Over the course of the past several decades, the concept that extracellular vesicles, exosomes and microvesicles, operate as cellular "housekeepers" and as agents for communication between and among cells and tissues, has emerged into one… read more here.
Keywords: extracellular vesicles; biochemistry; exosomes extracellular; path forward ... See more keywords
Exosomes and other extracellular vesicles-mediated microRNA delivery for cancer therapy
Sign Up to like & getrecommendations! Published in 2017 at "Translational cancer research"
DOI: 10.21037/16316
Abstract: Abstract: Extracellular vesicles (EVs), including exosomes and microvesicles, are critical mediators of cellto- cell communication in tissue homeostasis and repair, both in physiological and pathological conditions. Recently, progress has been achieved in their use in… read more here.
Keywords: extracellular vesicles; exosomes extracellular; delivery; cancer ... See more keywords