Structure and Dynamics of Type III Secretion Effector Protein ExoU As determined by SDSL-EPR Spectroscopy in Conjunction with De Novo Protein Folding
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DOI: 10.1021/acsomega.7b00349
Abstract: ExoU is a 74 kDa cytotoxin that undergoes substantial conformational changes as part of its function, that is, it has multiple thermodynamically stable conformations that interchange depending on its environment. Such flexible proteins pose unique… read more here.
Keywords: protein; biology; spectroscopy; structure ... See more keywords
The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis
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DOI: 10.1038/s41467-021-24337-9
Abstract: Pseudomonas aeruginosa can cause nosocomial infections, especially in ventilated or cystic fibrosis patients. Highly pathogenic isolates express the phospholipase ExoU, an effector of the type III secretion system that acts on plasma membrane lipids, causing… read more here.
Keywords: requires host; exou; bacterial toxin; exou requires ... See more keywords