Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides
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DOI: 10.1021/acscatal.3c00372
Abstract: Methionine sulfoxide reductase A (MsrA) enzymes have recently found applications as nonoxidative biocatalysts in the enantioselective kinetic resolution of racemic sulfoxides. This work describes the identification of selective and robust MsrA biocatalysts able to catalyze… read more here.
Keywords: chiral sulfoxides; expand substrate; sulfoxide reductase; resolution ... See more keywords