'Non-self' Mutation: Double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases.
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DOI: 10.1093/hmg/ddz096
Abstract: Inflammation is activated prior to symptoms in neurodegenerative diseases, providing a plausible pathogenic mechanism. Indeed genetic and pharmacological ablation studies in animal models of several neurodegenerative diseases demonstrate that inflammation is required for pathology. However,… read more here.
Keywords: repeat; rna; neurodegenerative diseases; pathology ... See more keywords