Expanded CUG Repeats Trigger Disease Phenotype and Expression Changes through the RNAi Machinery in C. elegans.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.03.003
Abstract: Myotonic dystrophy type 1 is an autosomal-dominant inherited disorder caused by the expansion of CTG repeats in the 3' untranslated region of the DMPK gene. The RNAs bearing these expanded repeats have a range of… read more here.
Keywords: repeats trigger; trigger disease; expanded cug; machinery ... See more keywords
Reversal of RNA toxicity in myotonic dystrophy via a decoy RNA-binding protein with high affinity for expanded CUG repeats
Sign Up to like & getrecommendations! Published in 2022 at "Nature Biomedical Engineering"
DOI: 10.1038/s41551-021-00838-2
Abstract: Myotonic dystrophy type 1 (DM1) is an RNA-dominant disease whose pathogenesis stems from the functional loss of muscleblind-like RNA-binding proteins (RBPs), which causes the formation of alternative-splicing defects. The loss of functional muscleblind-like protein 1… read more here.
Keywords: rna binding; expanded cug; myotonic dystrophy; rna ... See more keywords
Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.865811
Abstract: Myotonic dystrophy type 1 (DM1) is a dominantly inherited disorder due to a toxic gain of function of RNA transcripts containing expanded CUG repeats (CUGexp). Patients with DM1 present with multisystemic symptoms, such as muscle… read more here.
Keywords: expanded cug; rna; model cells; senescence ... See more keywords