Structural and Biochemical Features of OXA-517: a Carbapenem and Expanded-Spectrum Cephalosporin Hydrolyzing OXA-48 Variant
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DOI: 10.1128/aac.01095-22
Abstract: OXA-48-producing Enterobacterales have now widely disseminated throughout the world. Several variants have now been reported, differing by just a few amino-acid substitutions or deletions, mostly in the region of the loop β5-β6. ABSTRACT OXA-48-producing Enterobacterales… read more here.
Keywords: oxa 517; expanded spectrum; spectrum cephalosporin; structural biochemical ... See more keywords
Genetic Predictive Factors for Nonsusceptible Phenotypes and Multidrug Resistance in Expanded-Spectrum Cephalosporin-Resistant Uropathogenic Escherichia coli from a Multicenter Cohort: Insights into the Phenotypic and Genetic Basis of Coresistance
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DOI: 10.1128/msphere.00471-22
Abstract: The rising incidence of resistance to expanded-spectrum cephalosporins among Escherichia coli strains, the most common cause of UTIs, is threatening our ability to successfully empirically treat these infections. ESCR E. coli strains are often MDR;… read more here.
Keywords: resistance expanded; escherichia coli; blactx; expanded spectrum ... See more keywords
Multiplex Lateral Flow Immunoassay for the Detection of Expanded-Spectrum Hydrolysis and CTX-M Enzymes
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DOI: 10.3390/diagnostics12010190
Abstract: Background: Early detection of expanded-spectrum cephalosporinase (ESC) hydrolyzing ß-lactamases is essential for antibiotic stewardship. Here we have developed a multiplex lateral flow immunoassay (LFIA) that detects cefotaxime-hydrolyzing activity as well as the most prevalent ESC-hydrolyzing… read more here.
Keywords: multiplex lateral; flow immunoassay; expanded spectrum; lateral flow ... See more keywords