Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.
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DOI: 10.1021/acs.jmedchem.5b01888
Abstract: A hallmark of cancer is the evasion of apoptosis, which is often associated with the upregulation of the antiapoptotic members of the Bcl-2 family of proteins. The prosurvival function of the antiapoptotic Bcl-2 proteins is… read more here.
Keywords: bcl proteins; bcl family; antiapoptotic bcl; bcl ... See more keywords