The expanding landscape of ‘oncohistone’ mutations in human cancers
Sign Up to like & getrecommendations! Published in 2019 at "Nature"
DOI: 10.1038/s41586-019-1038-1
Abstract: Mutations in epigenetic pathways are common oncogenic drivers. Histones, the fundamental substrates for chromatin-modifying and remodelling enzymes, are mutated in tumours including gliomas, sarcomas, head and neck cancers, and carcinosarcomas. Classical ‘oncohistone’ mutations occur in… read more here.
Keywords: histone mutations; oncohistone mutations; mutations occur; expanding landscape ... See more keywords
Expanding the landscape of Spinocerebellar Ataxia type 5 (SCA5).
Sign Up to like & getrecommendations! Published in 2022 at "Neuropediatrics"
DOI: 10.1055/a-1849-8128
Abstract: Spinocerebellar ataxia type 5 (SCA5) is a rare subtype of SCA that usually affects adults. It has been recently reported in children in Europe, North America, and China. This study aims to describe clinical, radiological,… read more here.
Keywords: expanding landscape; ataxia type; spinocerebellar ataxia; sca5 ... See more keywords
Expanding the landscape of immunotherapy targets
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.362.6419.1124-t
Abstract: Cancer Most searches for druggable tumor-specific antigens (TSAs) start with an examination of peptides derived from protein-coding exons. Laumont et al. took a different approach and found numerous TSAs that derived from aberrant expression of… read more here.
Keywords: expanding landscape; cancer; landscape immunotherapy; immunotherapy targets ... See more keywords