Protective effects against tumors and infection by interleukin-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors
Sign Up to like & getrecommendations! Published in 2018 at "OncoImmunology"
DOI: 10.1080/2162402x.2017.1421892
Abstract: ABSTRACT Interleukin (IL)-27 is a multifunctional cytokine that belongs to the IL-6/IL-12 family and has potent antitumor activity through various mechanisms. Our novel findings indicate that IL-27 directly acts on hematopoietic stem cells and promotes… read more here.
Keywords: myeloid progenitors; expansion differentiation; stem cells; hematopoietic stem ... See more keywords
An allied reprogramming, selection, expansion and differentiation platform for creating hiPSC on microcarriers
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DOI: 10.1111/cpr.13256
Abstract: Induced pluripotent stem cells (iPSCs) generated by monolayer cultures is plagued by low efficiencies, high levels of manipulation and operator unpredictability. We have developed a platform, reprogramming, expansion, and differentiation on Microcarriers, to solve these… read more here.
Keywords: reprogramming selection; platform; expansion differentiation; allied reprogramming ... See more keywords
DAZL mediates a broad translational program regulating expansion and differentiation of spermatogonial progenitors
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DOI: 10.7554/elife.56523
Abstract: Fertility across metazoa requires the germline-specific DAZ family of RNA-binding proteins. Here we examine whether DAZL directly regulates progenitor spermatogonia using a conditional genetic mouse model and in vivo biochemical approaches combined with chemical synchronization… read more here.
Keywords: dazl; differentiation; differentiation spermatogonial; expansion differentiation ... See more keywords