Bioengineered 3D microfibrousâmatrix modulates osteopontin release from MSCs and facilitates the expansion of hematopoietic stem cells
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28175
Abstract: The osteopontin (OPN) released from mesenchymal stem cells (MSCs) undergoing lineage differentiation can negatively influence the expansion of hematopoietic stem cells (HSCs) in coculture systems developed for expanding HSCs. Therefore, minimizing the amount of OPN… read more here.
Keywords: matrix; mscs; expansion hematopoietic; expansion ... See more keywords
Update on preclinical and clinical efforts on ex-vivo expansion of hematopoietic stem and progenitor cells
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Hematology"
DOI: 10.1097/moh.0000000000000714
Abstract: Purpose of review Ex-vivo expansion of hematopoietic stem cells (HSCs) is one potential approach to enhance the clinical efficacy of hematopoietic cell transplantation-based therapy for malignant and nonmalignant blood diseases. Here, we discuss the major… read more here.
Keywords: preclinical clinical; hematopoietic stem; expansion hematopoietic; progenitor cells ... See more keywords