Expeditious and scalable preparation of a Li−Thiele reagent for amine-based bioconjugation
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DOI: 10.1016/j.cclet.2020.06.019
Abstract: Abstract Chemoselective amine bioconjugation has long been a challenge for native protein modification. Inspired by Thiele’s seminal discovery, Li and co-workers recently developed an ortho-phthalaldehyde (OPA) based reagent for labeling the amino group of a… read more here.
Keywords: reagent; bioconjugation; scalable preparation; amine ... See more keywords