IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
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DOI: 10.1038/s41467-019-10444-1
Abstract: The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP… read more here.
Keywords: hif1 pfkfb3; pfkfb3 signaling; iapp; activates hif1 ... See more keywords